| Identification | Back Directory | [Name]
DODMA | [CAS]
104162-47-2 | [Synonyms]
DODMA
2-amino-2,3-dimethyloleanol
1,2-Dioleyloxy-3-(dimethylamino)propane
2,3-Dioleyloxy-1-(dimethylamino)propane
1,2-Dioleyloxy-3-dimethylamino-propane (DODMA)
2,3-Dioleyloxy-1-(dimethylamino)propane >=98.0% (TLC)
N,N-Dimethyl-2,3-bis[(9Z)-9-octadecen-1-yloxy]-1-propanamine
1-Propanamine, N,N-dimethyl-2,3-bis[(9Z)-9-octadecen-1-yloxy]-
1-Propanamine, N,N-dimethyl-2,3-bis[(9Z)-9-octadecenyloxy]-, (2S)- | [Molecular Formula]
C41H81NO2 | [MDL Number]
MFCD22200991 | [MOL File]
104162-47-2.mol | [Molecular Weight]
620.09 |
| Chemical Properties | Back Directory | [Boiling point ]
649.7±55.0 °C(Predicted) | [density ]
0.869±0.06 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
Soluble in Ethanol, DMSO, DMF | [pka]
8.65±0.28(Predicted) | [BRN ]
10139013 | [InChI]
InChI=1S/C41H81NO2/c1-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-35-37-43-40-41(39-42(3)4)44-38-36-34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-2/h19-22,41H,5-18,23-40H2,1-4H3/b21-19-,22-20- | [InChIKey]
GLGLUQVVDHRLQK-WRBBJXAJSA-N | [SMILES]
C(N(C)C)C(OCCCCCCCC/C=C\CCCCCCCC)COCCCCCCCC/C=C\CCCCCCCC |
| Hazard Information | Back Directory | [Description]
1,2-Dioleyloxy-3-dimethylamino-propane (DODMA,104162-47-2) is a cationic lipid containing the unsaturated long-chain (18:1) oleic acid inserted at both the sn-1 and sn-2 positions. It has been used in the composition of liposomes formulated as stable nucleic acid lipid particles that can encapsulate siRNA or other small molecules to be used for drug delivery.1,2
| [Chemical Properties]
DODMA(104162-47-2) is a colourless to light yellow liquid; soluble in ethanol, DMSO, DMF; stored at -20℃.
| [Uses]
1,2-Dioleyloxy-3-dimethylamino-propane(104162-47-2) is a cationic lipid containing the unsaturated long-chain (18:1) oleic acid inserted at both the sn-1 and sn-2 positions. It has been used in the composition of lipospomes formulated as stable nucleic acid lipid particles that can encapsulate siRNA or other small molecules to be used for drug delivery.[Cayman Chemical]
| [Application]
DODMA(104162-47-2) is suitable for use in the preparation of lipid nanoparticles (LNPs).
| [Biochem/physiol Actions]
DODMA (1,2-dioleyloxy-3-dimethylaminopropane,104162-47-2) is used in the preparation of cationic liposomes and lipid nanoparticles (LNPs). LNPs with DODMA has low or neutral zeta potential. DODMA is efficient in encapsulating nucleic acid during synthesis by reducing the physiological pH. DODMA is implicated in gene therapy.
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