| Identification | Back Directory | [Name]
chlormethine N-oxide hydrochloride | [CAS]
302-70-5 | [Synonyms]
Hn20 hydrochloride
Mbao hydrochloride
Mechlorethaminoxyde
Hn2 oxide hydrochloride
Chlormethine N-oxide HCl
mustine N-oxide hydrochloride
chlormethine N-oxide hydrochloride
NITROGENMUSTARDN-OXIDEHYDROCHLORIDE
MECHLORETHAMINE OXIDE HYDROCHLORIDE
2,2'-Dichloro-N-methyldiethylamine N-oxide hydrochloride
Diethylamine, 2,2'-dichloro-N-methyl-, N-oxide, hydrochloride
2-Chloro-N-(2-chloroethyl)-N-methylethanamine-N-oxide hydrochloride
Ethanamine, 2-chloro-N-(2-chloroethyl)-N-methyl-, N-oxide, hydrochloride | [Molecular Formula]
C5H12Cl3NO | [MOL File]
302-70-5.mol | [Molecular Weight]
208.514 |
| Safety Data | Back Directory | [RIDADR ]
3249 | [HazardClass ]
6.1(a) | [PackingGroup ]
II | [Safety Profile]
Suspected carcinogen
with experimental tumorigenic data. Poison
by ingestion, subcutaneous, intravenous, and
intraperitoneal routes. Mutation data
reported. An antineoplastic agent. When
heated to decomposition it emits toxic
fumes of Cland NOx.
| [Hazardous Substances Data]
302-70-5(Hazardous Substances Data) | [Toxicity]
LD50 oral in rat: 60mg/kg |
| Hazard Information | Back Directory | [Definition]
ChEBI: Nitrogen mustard N-oxide hydrochloride is a nitrogen mustard. | [Carcinogenicity]
Nitrogen mustard N-oxide is
reportedly carcinogenic in mice and rats. Following subcutaneous
administration in mice, it produced lung tumors,
thymic lymphomas, and Harderian gland adenomas. Mice
given two weekly injections either intravenously, intraperitoneally,
or subcutaneously for 15 weeks showed an increase
in lymphomas, fibrosarcomas, pulmonary adenomas, and
liver hemangiomas. In rats given the material intravenously,
it mainly produced lymphoreticular tumors and
sarcomas. The preceding data were evaluated by the IARC
and considered “sufficient evidence of carcinogenicity in
animals.” Based on this evaluation and its mutagenic potential,
the IARC classified nitrogen mustard N-oxide in Group
2B (possibly carcinogenic to humans). |
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