(1R trans)-2-(3,4-difluorophenyl)cyclopropane amine
- CAS No.
- 1156491-10-9
- Chemical Name:
- (1R trans)-2-(3,4-difluorophenyl)cyclopropane amine
- Synonyms
- (1S,2R)-2-(3,4-difluorophenyl)cyclopropanaMine;(1R,2S)-rel-2-(3,4-Difluorophenyl)cyclopropanamine hydrochloride;(1R,2S)-2-(3,4-difluorophenyl)cyclopropanaMine Hydrochloride(1:1);(1R trans)-2-(3,4-difluorophenyl)cyclopropane aMine hydrochloride;Ticagrelor USP RC A;Ticagrelor side chain 2 hydrochloride;2-(3,4-Difluoro-phenyl)-cyclopropylamine;(1R,2S)-rel-2-(3,4- Difluorophenyl)cyclo;(1R,2S)-rel-2-(3,4-Difluorophenyl)cyclopropanami;(1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine HCl
- CBNumber:
- CB22498775
- Molecular Formula:
- C9H10ClF2N
- Molecular Weight:
- 205.63
- MDL Number:
- MFCD16875501
- MOL File:
- 1156491-10-9.mol
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
---|---|
Signal word | Warning |
Hazard statements | H302-H315-H319-H335 |
Precautionary statements | P261-P305+P351+P338 |
(1R trans)-2-(3,4-difluorophenyl)cyclopropane amine price More Price(11)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
ChemScene | CS-M1888 | (1R,2S)-rel-2-(3,4-Difluorophenyl)cyclopropanaminehydrochloride ≥99.0% | 1156491-10-9 | 25g | $188 | 2021-12-16 | Buy |
Medical Isotopes, Inc. | 93228 | (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamineHydrochloride | 1156491-10-9 | 250mg | $370 | 2021-12-16 | Buy |
AK Scientific | J96448 | (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanaminehydrochloride | 1156491-10-9 | 25g | $500 | 2021-12-16 | Buy |
Alichem | 1156491109 | (1R,2S)-rel-2-(3,4-Difluorophenyl)cyclopropanaminehydrochloride | 1156491-10-9 | 25g | $505 | 2021-12-16 | Buy |
Chemenu | CM117627 | trans-2-(3,4-Difluorophenyl)cyclopropanamineHydrochloride 95+% | 1156491-10-9 | 1000g | $960 | 2021-12-16 | Buy |
(1R trans)-2-(3,4-difluorophenyl)cyclopropane amine Chemical Properties,Uses,Production
Physical Form
Solid
Uses
(1S,2R)-2-(3,4-Difluorophenyl)-cyclopropanamine is an intermediate used to prepare ticagrelor (T437700).
Synthesis Reference(s)
Synthesis of 2-(3,4-difluorophenyl)cyclopropanamine derivatives and salts. EU Patent EP2644590A1
Synthesis
1,2-Difluorobenzene is reacted with 3-chloropropionyl chloride to produce 3-chloro-1-(3',4'-difluorophenyl)-propan-1-one, which is by addition of N,N-dimethylformamide, phloroglucinol and sodium iodide in the next step converted to 1-(3',4'-difluorophenyl)-3-nitro-propan-1-one. The keto group of the latter intermediate is in the subsequent step stereochemically reduced to hydroxyl group by the use of chiral oxazaborolidine together with borane dimethyl sulfide or borane-N,N-diethyl aniline complex in the presence of tetrahydrofurane. The obtained (1R)-1-(3',4'-difluorophenyl)-3-nitro-propan-1-ol is then added to a mixture of triphenylphosphine and diethylazodicarboxylate in benzene to yield (1S,2R)-2-(3',4'-difluorophenyl)-1-nitrocyclopropane, which is in the last step converted to 2-(3,4-difluorophenyl)cyclopropane amine by reduction of the nitro group by catalytic hydrogenation with palladium catalyst and zink dust.
(1R trans)-2-(3,4-difluorophenyl)cyclopropane amine Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Shanghai Safer Pharmaceutical Technology Co., Ltd. | 021-31761238 | sales@saferph.com | CHINA | 897 | 58 |
Shanghai Jinli Pharmaceutical Co.,Ltd | +86-21-57256005 +86-15921811235 | chang@shjlchem.com | China | 20 | 58 |
Hebei Yanxi Chemical Co., Ltd. | +8617531190177 | peter@yan-xi.com | China | 6011 | 58 |
Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 19368 | 58 |
hebei hongtan Biotechnology Co., Ltd | +86-86-1913198-3935 +8617331935328 | sales03@chemcn.cn | China | 971 | 58 |
Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 15954 | 58 |
Nanjing Gold Pharmaceutical Technology Co. Ltd. | 025-84209270 15906146951 | CHINA | 115 | 55 | |
Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 | sales01@cooperate-pharm.com | CHINA | 1811 | 55 |
Hi-Tech Chemistry Corp | 0519-86626038 | yuhh@hitechem.com | CHINA | 811 | 58 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21687 | 55 |
View Lastest Price from (1R trans)-2-(3,4-difluorophenyl)cyclopropane amine manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2024-06-07 | (1R,2S)-rel-2-(3,4-Difluorophenyl)cyclopropanamine hydrochloride
1156491-10-9
|
US $5.00 / kg | 1kg | ≥99% | 20mt/year | Jinan Finer Chemical Co., Ltd | ||
2024-06-07 | (1R,2S)-rel-2-(3,4-Difluorophenyl)cyclopropanamine hydrochloride
1156491-10-9
|
US $30.00 / kg | 1kg | 98% | 2000kg | hebei hongtan Biotechnology Co., Ltd | ||
2024-04-27 | (1R trans)-2-(3,4-difluorophenyl)cyclopropane amine
1156491-10-9
|
US $30.00-0.90 / KG | 1KG | 99% | g-kg-tons, free sample is available | Henan Fengda Chemical Co., Ltd |
- (1R,2S)-rel-2-(3,4-Difluorophenyl)cyclopropanamine hydrochloride
1156491-10-9
- US $5.00 / kg
- ≥99%
- Jinan Finer Chemical Co., Ltd
- (1R,2S)-rel-2-(3,4-Difluorophenyl)cyclopropanamine hydrochloride
1156491-10-9
- US $30.00 / kg
- 98%
- hebei hongtan Biotechnology Co., Ltd
- (1R trans)-2-(3,4-difluorophenyl)cyclopropane amine
1156491-10-9
- US $30.00-0.90 / KG
- 99%
- Henan Fengda Chemical Co., Ltd
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