ウミロリムス

ウミロリムス 価格

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ウミロリムス 化学特性,用途語,生産方法

効能

免疫抑制薬

説明

Coronary stents have dramatically improved the success rate of interventional cardiology in recent years, and stent implantation has become the standard of care in percutaneous coronary interventions. However, the long-term success of coronary stenting is hampered by a high rate of restenosis (i.e., recurrence of stenosis, or reblocking), which is caused by proliferation and migration of smooth muscle cells and production of extracellular matrix. The Biomatrix DES is a novel stent system combining a biodegradable PLA and the new anti-restenoic drug biolimus. Biolimus is a semi-synthetic analog of sirolimus wherein the hydroxyl moiety at position 42 is modified to an ethoxyethyl ether group. As with rapamycin, the mechanism of action of biolimus consists of forming a complex with intracellular 12-kDa FK506-binding protein (FKBP-12), which binds to the mammalian target of rapamycin (mTOR) and reversibly inhibits cell-cycle transition of proliferating smooth muscle cells.The antiproliferative potency of biolimus is similar to that of sirolimus; however, it is approximately 10-fold more lipophilic than sirolimus, which results in rapid absorption of the drug into fatty tissues and reduced systemic exposure. The Biomatrixs DES is produced by the absorption of a 1:1 combination of biolimus and PLA on a flexible stainless steel stent. The precision automated coating method used in the production of the stent ensures the PLA biolimus combination is applied solely to the abluminal surface of the stent. PLA is co-released with biolimus over 6 9 months, and biodegraded initially to lactic acid, and eventually to carbon dioxide and water.

使用

Umirolimus is a semi-synthetic macrocyclic lactone prepared from rapamycin by selective alkylation of the 42-hydroxy group, providing one of most hydrophobic tacrolimus analogues. Umirolimus has been targeted for use in stents and medical devices to suppress localised immunoreaction. Like all tacrolimus analogues, umirolimus binds to receptor protein, FKBP12. The complex then binds to mTOR and prevents it from interacting with target proteins. Umirolimus is extensively cited in the literature with over 70 citations.

ウミロリムス 上流と下流の製品情報

原材料

準備製品

ウミロリムス 生産企業

名前	電話番号	電子メール	国籍	製品カタログ	優位度
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28180	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
BOC Sciences	16314854226; +16314854226	inquiry@bocsci.com	United States	19743	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	52927	58
LGM Pharma	1-(800)-881-8210	inquiries@lgmpharma.com	United States	2127	70
ChemStrong Scientific Co.,Ltd	0755-0755-66853366 13670046396	sales@chem-strong.com	China	17993	56
Lynnchem	86-(0)29-85992781 17792393971	info@lynnchem.com	China	4587	58
Novachemistry	44-20819178-90 02081917890	info@novachemistry.com	United Kingdom	4381	58
Wuhan FengyaoTonghui Chemical Products Co., Ltd.	027-87466105 15377573527	2678564200@qq.com	China	17997	58
Shanghai Hongye Biotechnology Co. Ltd	400-9205774	sales@glpbio.cn	China	6870	58

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• 851536-75-9
• BioliMus
• BioliMus, BioliMus A9, TRM 986
• BIOLIMUS A9
• UMiroliMus
• Rapamycin, 42-O-(2-ethoxyethyl)-
• BioliMus A9 UMiroliMus
• TRM 986
• TRM986
• TRM-986
• ウミロリムス
• バイオリムスA9
• バイオリムスA-9
• (3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-ヘキサデカヒドロ-9,27-ジヒドロキシ-3-[(1R)-2-[(1S,3R,4R)-4-(2-エトキシエトキシ)-3-メトキシシクロヘキシル]-1-メチルエチル]-10,21-ジメトキシ-6,8,12,14,20,26-ヘキサメチル-23,27-エポキシ-3H-ピリド[2,1-c][1,4]オキサアザシクロヘントリアコンチン-1,5,11,28,29(4H,6H,31H)-ペンタオン
• (1R,9S,12S,15R,16E,18R,19R,21R,23S,24E,26E,28E,30S,32S,35R)-12-[(2R)-1-[(1S,3R,4R)-4-(2-エトキシエトキシ)-3-メトキシシクロヘキシル]プロパン-2-イル]-1,18-ジヒドロキシ-19,30-ジメトキシ-15,17,21,23,29,35-ヘキサメチル-11,36-ジオキサ-4-アザトリシクロ[30.3.1.04,9]ヘキサトリアコンタ-16,24,26,28-テトラエン-2,3,10,14,20-ペンタオン
• バイオリムス
• (16E,24E,26E,28E)-12-[2-(4-ヒドロキシ-3-メトキシシクロヘキシル)-1-メチルエチル]-1,18-ジヒドロキシ-19,30-ジメトキシ-15,17,21,23,29,33-ヘキサメチル-11,36-ジオキサ-4-アザトリシクロ[30.3.1.04,9]ヘキサトリアコンタン-16,24,26,28-テトラエン-2,3,10,14,20-ペンタオン
• (16E,24E,26E,28E)-1,18-ジヒドロキシ-12-[1-(4-ヒドロキシ-3-メトキシシクロヘキシル)プロパン-2-イル]-19,30-ジメトキシ-15,17,21,23,29,33-ヘキサメチル-11,36-ジオキサ-4-アザトリシクロ[30.3.1.04,9]ヘキサトリアコンタ-16,24,26,28-テトラエン-2,3,10,14,20-ペンタオン
• ビオリムス
• ビオリムスA9
• 42-O-(2-エトキシエチル)ラパマイシン