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| Product Name: | AR7 | | Synonyms: | AR7;7-Chloro-3-(4-methylphenyl)-2H-1,4-benzoxazine;7-Chloro-3-p-tolyl-2H-benzo[b][1,4]oxazine;Atypical retinoid 7;Thyroid Hormone receptor,α1 human;c-ERBA-1;ERBA;ERB-T-1 | | CAS: | 80306-38-3 | | MF: | C15H12ClNO | | MW: | 257.71 | | EINECS: | | | Product Categories: | | | Mol File: | 80306-38-3.mol |  |
| storage temp. | Sealed in dry,2-8°C | | solubility | DMSO: soluble20mg/mL, clear | | form | powder | | color | white to beige | | Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month. |
| Hazard Codes | N | | Risk Statements | 50/53 | | Safety Statements | 60-61 | | RIDADR | UN 3077 9 / PGIII | | WGK Germany | 3 |
| Description | AR7 (80306-38-3) is an atypical retinoid which acts as an RARα antagonist and activates chaperone-mediated autophagy (CMA) via an RAR-dependent pathway.1 Downstream signaling results in an increase of LAMP-2A expression.1 Cells pretreated with AR7 had markedly improved viability in a paraquat-induced oxidative stress model.1 AR7 stimulated CMA and attenuated accumulation of SNCA oligomers in prolonged cultures of mutant cortical neurons2 indicating that CMA activation may be a viable disease modifying strategy in Parkinson’s disease3. A targetome analysis of AR7-induced CMA in cancer cells has been performed.4 | | Uses | AR 7 is a CMA booster. Used in biological study of chemical modulation of chaperone-?mediated autophagy by retinoic acid derivatives. | | References | Anguiano et al. (2013), Chemical modulation of chaperone-mediated autophagy by retinoic acid derivatives; Nat. Chem. Biol. 9 374
Ho et al. (2020), Age-dependent accumulation of oligomeric SNCA/α-synuclein from impaired degradation in mutant LRRK2 knockin mouse model of Parkinson disease: role for therapeutic activation of chaperone-mediated autophagy (CMA); Autophagy 16 347
Bonam et al. (2021), Autophagy-Lysosomal Pathway as Potential Therapeutic Target in Parkinson’s Disease; Cells 10 3547
Hao et al. (2019), Targetome analysis of chaperone-mediated autophagy in cancer cells; Autophagy 15 1558 |
| | AR7 Preparation Products And Raw materials |
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