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Disopyramide

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Disopyramide Basic information
Product Name:Disopyramide
Synonyms:
CAS:373-79-5
MF:
MW:0
EINECS:
Product Categories:
Mol File:Mol File
Disopyramide Structure
Disopyramide Chemical Properties
Safety Information
MSDS Information
Disopyramide Usage And Synthesis
Clinical UseVentricular and supraventricular arrhythmias
Drug interactionsPotentially hazardous interactions with other drugs
Anti-arrhythmics: increased myocardial depression with other anti-arrhythmics; amiodarone and dronedarone increase risk of ventricular arrhythmias - avoid.
Antibacterials: concentration possibly increased by azithromycin, clarithromycin and erythromycin (risk of toxicity); increased risk of ventricular arrhythmias with moxifloxacin - avoid; possibly increased risk of ventricular arrhythmias with telithromycin and delamanid; concentration reduced by rifamycins.
Antidepressants: increased risk of ventricular arrhythmias with tricyclics; increased risk of ventricular arrhythmias with citalopram and escitalopram - avoid.
Antifungals: increased risk of ventricular arrhythmias with ketoconazole - avoid; avoid with itraconazole.
Antihistamines: increased risk of ventricular arrhythmias with mizolastine.
Antihypertensives: increased myocardial depression and asystole with beta-blockers or verapamil; increased risk of ventricular arrhythmias with sotalol
Antimuscarinics: increased risk of antimuscarinic side effects; increased risk of ventricular arrhythmias with tolterodine.
Antivirals: concentration possibly increased by ritonavir, increased risk of toxicity; increased risk - avoid.
MetabolismDisopyramide is partially metabolised in the liver by the cytochrome P450 isoenzyme CYP3A4. The major metabolite is mono-N-dealkylated disopyramide which retains some antiarrhythmic and antimuscarinic activity. The major route of excretion is through the kidney, about 50-60% as the unchanged drug, 20% as the N-dealkylated metabolite, and 10% as other metabolites. 64% of the N-dealkylated metabolite is excreted via the faeces.
Disopyramide Preparation Products And Raw materials
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