2-Aminofluorene synthesis
- Product Name:2-Aminofluorene
- CAS Number:153-78-6
- Molecular formula:C13H11N
- Molecular Weight:181.23
607-57-8
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153-78-6
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Yield:153-78-6 99%
Reaction Conditions:
with sodium tetrahydroborate in methanol;water at 0 - 50; for 2 h;
Steps:
Reduction in presence of NaBH4 (Method A)
General procedure: A mixture of nitroarene (1 mmol), SS-Pd (2 mol% Pd) and sodium borohydride (3 mmol) were taken in a 25 ml round bottomed flask. 3 ml of MeOH:H2O (3:7) was added to the mixture by a syringe at 0 oC in stirring condition. After 10 minutes the reaction mixture was heated to 50 oC. Progress of the reaction was monitored by TLC. On completion, the reaction mixture was extracted with ethylacetate and dried over anhydrous Na2SO4. Evaporation of the combined organic layer and followed by column chromatography over silica gel (60-120 mesh) afforded desired corresponding amines.
References:
Shil, Arun K.;Sharma, Dharminder;Guha, Nitul Ranjan;Das, Pralay [Tetrahedron Letters,2012,vol. 53,# 36,p. 4858 - 4861] Location in patent:supporting information; experimental part
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153-78-6
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