ChemicalBook CAS DataBase List 5-fluoropyrimidin-4-amine

5-fluoropyrimidin-4-amine synthesis

2synthesis methods

Product Name:5-fluoropyrimidin-4-amine
CAS Number:811450-26-7
Molecular formula:C4H4FN3
Molecular Weight:113.09

347418-42-2
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$37.00/1g

811450-26-7
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$59.00/100mg

Yield: 58%

Reaction Conditions:

with ammonia in methanol

Steps:

71.A 5-Fluoro-4-pyrimidinamine
Pre Step A
5-Fluoro-4-pyrimidinamine
A mixture of 4-chloro-5-fluoropyrimidine (200 mg, 1.509 mmol) and ammonia (3.3 ml, 45.3 mmol) in methanol (580 μl) was heated to 110° C. via a microwave reactor for 30 min.
The reaction was filtered and the solid was dried to give 5-fluoro-4-pyrimidinamine (100 mg, 0.875 mmol, 58% yield) as a white solid. MS (ES+) m/z 114.1 (MH⁺).

References:

Glaxosmithkline LLC;Aubart, Kelly M.;Benowitz, Andrew B.;Fang, Yuhong;Hoffman, James;Karpinski, Joseph M.;Knox, Andrew Nicholson;Liao, Xiangmin;Qin, Donghui;Shi, Dongchuan;Spletstoser, Jared T. US2013/345120, 2013, A1 Location in patent:Page/Page column

347418-42-2
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$37.00/1g

Ethanamine, N-[(3,5-dichlorophenyl)methylene]-2,2-diethoxy-

1000210-73-0
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811450-26-7
93 suppliers
$59.00/100mg

References

5-fluoropyrimidin-4-amine Related Search:

5-Fluoropyrimidine 5-Fluorouracil 2-Methoxy-5-fluoro-4-aminopyrimidine