ChemicalBook CAS DataBase List D-Mannitol

D-Mannitol synthesis

7synthesis methods

Product Name:D-Mannitol
CAS Number:69-65-8
Molecular formula:C6H14O6
Molecular Weight:182.17

Mannitol may be extracted from the dried sap of manna and other natural sources by means of hot alcohol or other selective solvents. It is commercially produced by the catalytic or electrolytic reduction of monosaccharides such as mannose and glucose.

3458-28-4 Synthesis

3458-28-4
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69-65-8
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Yield:69-65-8 100%

Reaction Conditions:

with hydrogen in lithium hydroxide monohydrate at 120; under 15001.5 Torr; for 1 h;

Steps:

12 Example: 12

To 0.5 g of mannose in 40 ml of H20, HRO/Na-β catalyst (50 mg) was added in a reactor vessel. The reactor vessel was then heated at 120 °C for 1 h under H2 pressure (20 bar). After completion of the reaction, the catalyst was separated by using centrifuge and the obtained clear product mixture was analyzed by UHPLC. The reaction gave 100% conversion ofmannose with 100% yield of mannitol.

References:

WO2017/60922,2017,A1 Location in patent:Page/Page column 12; 20

57-48-7 Synthesis