ChemicalBook CAS DataBase List Isotretinoin

Isotretinoin synthesis

9synthesis methods

Product Name:Isotretinoin
CAS Number:4759-48-2
Molecular formula:C20H28O2
Molecular Weight:300.44

Preparation of isotretinoin in a single step from β-ionone and ethyl chloride are first reacted together after which the product is further reacted with triphenylphosphine to obtain Triphenyl salt. The Triphenyl salt is further reacted with cyclopentenone derivative to produce isotretinoin and its 8Z isomer. separate out the 8Z isomer and convert it to isotretinoin through isomerization with the help of nitric acid.

1-Penten-4-yn-3-ol, 3-methyl-1-(2,6,6-trimethyl-1-cyclohexen-1-yl)-, (1E)-

17974-59-3
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4759-48-2
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Yield:-

Steps:

Multi-step reaction with 4 steps
1: 1.) ethylmagnesium bromide / 1.) THF, r.t., 1.5 h; 2.) THF, r.t., 1 h
2: 81 percent / LiAlH₄ / tetrahydrofuran; diethyl ether / 55 °C
3: 60 percent / LiAlH₄, titanium trichloride, triethylamine / tetrahydrofuran; diethyl ether / 0.5 h / 50 °C

References:

Solladie, G.;Berl, V. [Bulletin de la Societe Chimique de France,1993,vol. 130,p. 568 - 574]

59699-82-0 Synthesis

59699-82-0
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4759-48-2
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References

2H-Pyran-2-one, 5,6-dihydro-4-methyl-6-[(1E,3E)-2-methyl-4-(2,6,6-trimethyl-1-cyclohexen-1-yl)-1,3-butadien-1-yl]-

43059-50-3
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4759-48-2
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References

81176-73-0
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4759-48-2
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References

20013-34-7
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4759-48-2
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302-79-4 Synthesis

302-79-4
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References

Isotretinoin Related Search:

Folic acid Ethyl 2-(Chlorosulfonyl)acetate Dimethyl sulfoxide Dimethyl ether Citric acid Ascorbic Acid Dimethyl sulfone Menadione Dimethyl carbonate N,N-Dimethylaniline