ChemicalBook CAS DataBase List Thiamine hydrochloride

Thiamine hydrochloride synthesis

6synthesis methods

Product Name:Thiamine hydrochloride
CAS Number:67-03-8
Molecular formula:C12H17N4OS.ClH.Cl
Molecular Weight:337.27

By linking the preformed thiazole and pyrimidine ring system.

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Yield:67-03-8 94.7%

Reaction Conditions:

with hydrogenchloride;dihydrogen peroxide in water at -10; for 20 h;

Steps:

3 Example 3

A thiophene thiamine 50 g was added to a three-necked flask,31% hydrochloric acid 60 g,Into the freezer tank to cool down to minus 10 .Slowly dropping hydrogen peroxide 30g,Hydrogen peroxide content of 20%,When the temperature is controlled at minus 10 ° C,The reaction was then incubated at minus 10 ° C for 20 hours.After the insulation,Keep the temperature below 0 ,filter,Washed with 50 g of methanol,After drying the weight of chlorinated thiazolium hydrochloride 48.1 g,Yield 94.7%Quality analysis qualified.

References:

CN105884759,2016,A Location in patent:Paragraph 0027; 0028; 0029; 0030; 0031; 0032

137-00-8 Synthesis