| Identification | Back Directory | [Name]
AMASTATIN HYDROCHLORIDE | [CAS]
100938-10-1 | [Synonyms]
AMASTATIN
AMASTATIN HCL
AMASTATIN HYDROCHLORIDE
AMASTATIN HYDROCHLORIDE HYDRATE
H-(2S,3R)-AHMH-VAL-VAL-ASP-OH HCL
Amastatin hydrate hydrochloride
4-formylphenyl-O-β-d-allopyranoside
N((2S 3R)3-AMINO-2-HXY-5-ME.HEXANOYL)-L&
Amastatinhydrochloridebiochemikasynthetic
(2S,3R)-[3-AMINO-2-HYDROXY-5-METHYLHEXANOYL]-VAL-VAL-ASP-OH HCL
[(2S,3R)-3-AMINO-2-HYDROXY-5-METHYLHEXANOYL]-VAL-VAL-ASP HYDROCHLORIDE
(2s,3r)-3-amino-2-hydroxy-5-methylhexanoyl-val-val-asp hydrochloride hydrate
(2S,3R)-3-Amino-2-hydroxy-5-methylhexanoyl-Val-Val-Asp hydrate hydrochloride
(Amino-2-hydroxy-5-methyl-hexanoyl)-L-valyl-L-valyl-L-aspartic acid hydrochloride salt
L-Aspartic acid,N-[(2S,3R)-3-amino-2-hydroxy-5-methyl-1-oxohexyl]-L-valyl-L-valyl-,monohydrochloride (9CI) | [EINECS(EC#)]
999-999-2 | [Molecular Formula]
C21H39ClN4O8 | [MDL Number]
MFCD00058071 | [MOL File]
100938-10-1.mol | [Molecular Weight]
511.01 |
| Chemical Properties | Back Directory | [Melting point ]
202-205 °C | [storage temp. ]
-20°C | [solubility ]
methanol: 5 mg/mL, clear, colorless
| [form ]
White to off-white powder. | [color ]
White to off-white | [BRN ]
8888370 |
| Hazard Information | Back Directory | [Uses]
Amastatin is a slow, tight binding, competitive aminopeptidase (AP) inhibitor, first described as an inhibitor of human serum AP-A (glutamyl AP; IC50 = 0.54 μg/ml) but not of AP-B (arginine AP). It also inhibits AP-N (AP-M, alanyl AP; Ki = 20-200 nM), leucyl-cystinyl AP (Ki = 20-220 nM), and endoplasmic reticulum AP 1 (Ki = 41.8 μM). Amastatin is without effect on trypsin, papain, chymotrypsin, elastase, pepsin, or thermolysin.[Cayman Chemical] | [General Description]
Chemical structure: peptide | [Biochem/physiol Actions]
It inhibits cytosolic leucine aminopeptidase (EC.3.4.11.1), microsomal aminopeptidase M (EC.3.4.11.2) and bacterial leucine aminopeptidase (EC.3.4.11.10). It is less effective against aminopeptidase A (EC 3.4.11.7), the enzyme that converts angiotensin II to angiotensin III. Potentiates the CNS effects of vasopressin and oxytocin in vivo.Effective concentration: 1-10 μM. | [storage]
Store at -20°C |
|
|