| Identification | Back Directory | [Name]
PYRROLNITRIN | [CAS]
1018-71-9 | [Synonyms]
52230
A-10338
pyroace
nsc-107654
pyrollnitrin
Antibiotic A-10338
3-chloro-4-(3-chloro-2-nitrophenyl)-pyrrol
3-chloro-4-(2’-nitro-3’-chlorophenyl)pyrrole
PYRROLE,3-CHLORO-4-(3-CHLORO-2-NITROPHENYL)-
3-chloro-4-(3-chloro-2-nitrophenyl)-1H-pyrrole
3-chloro-4-(3-chloro-2-nitro-phenyl)-1H-pyrrole
1H-Pyrrole, 3-chloro-4-(3-chloro-2-nitrophenyl)- | [EINECS(EC#)]
213-812-7 | [Molecular Formula]
C10H6Cl2N2O2 | [MDL Number]
MFCD00865605 | [MOL File]
1018-71-9.mol | [Molecular Weight]
257.07 |
| Chemical Properties | Back Directory | [Melting point ]
124.5° | [Boiling point ]
410.5±45.0 °C(Predicted) | [density ]
1.5834 (rough estimate) | [refractive index ]
1.6100 (estimate) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: 10 mM | [form ]
A solid | [pka]
14.28±0.50(Predicted) |
| Hazard Information | Back Directory | [Description]
Pyrrolnitrin, isolated from Pseudomonas
species, is highly active against fungi,
particularly trichophyte species. | [Uses]
Antifungal. | [Definition]
ChEBI: A member of the class of pyrroles carrying chloro and 3-chloro-2-nitrophenyl substituents at positions 3 and 4 respectively. | [Origin]
Pyrrolnitrin was found in the cells of Pseudomonas pyrrocinia grownin a medium containing a high concentration of inorganic phosphate.It was discovered by Arima of the University of Tokyo in collaboration with Fujisawa Pharmaceutical Industries Co. in 1965. | [Biological Activity]
Pyrrolnitrin shows strong activity against a variety of fungi and weak activity against grampositive bacteria.
| [Biochem/physiol Actions]
Pyrrolnitrin blocks the terminal electron transport between succinate or reduced NADH and coenzyme Q. In mitochondria preparations of S. cerevisiae, the antibiotic inhibited succinate oxidase, NADH oxidase, succinate cythochrome C reductase, and NADH-cytochrome C reductase. Pyrrolnitrin is involved in many cellular processes such as oxidative stress, electron transport, DNA and RNA synthesis. | [storage]
Store at -20°C |
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