| Identification | Back Directory | [Name]
CP466722 | [CAS]
1080622-86-1 | [Synonyms]
CS-73
CP466722
CP-466722, >98%
CP-466722;CP466722
CP466722 USP/EP/BP
CP466722 >=98% (HPLC)
CP466722;CP 466722;CP-466722
2-(6,7-dimethoxyquinazolin-4-yl)-5-pyridin-2-yl-1,2,4-triazol-3-amine
1-(6,7-Dimethoxy-4-quinazolinyl)-3-(2-pyridinyl)-1H-1,2,4-triazol-5-amine
2-(6,7-dimethoxyquinazolin-4-yl)-5-(pyridin-2-yl)-2H-1,2,4-triazol-3-amine
1-(6,7-Dimethoxyquinazolin-4-yl)-3-(pyridin-2-yl)-1H-1,2,4-triazol-5-amine
1H-1,2,4-Triazol-5-amine, 1-(6,7-dimethoxy-4-quinazolinyl)-3-(2-pyridinyl)-
1-(6,7-Dimethoxy-4-quinazolinyl)-3-(2-pyridinyl)-1H-1,2,4-triazol-5-amine CP 466722 | [EINECS(EC#)]
808-414-0 | [Molecular Formula]
C17H15N7O2 | [MDL Number]
MFCD17392566 | [MOL File]
1080622-86-1.mol | [Molecular Weight]
349.35 |
| Chemical Properties | Back Directory | [Boiling point ]
642.3±65.0 °C(Predicted) | [density ]
1.48 | [storage temp. ]
2-8°C | [solubility ]
DMSO: soluble0.5mg/mL, clear (warmed) | [form ]
powder | [pka]
0.00±0.19(Predicted) | [color ]
white to beige |
| Hazard Information | Back Directory | [Description]
CP 466,722 is an inhibitor of ataxia-telangiectasia mutated (ATM) kinase that inhibits ionizing radiation-induced ATM autophosphorylation and phosphorylation of the ATM targets SMC1, Chk2, and p53 in HeLa cells when used at a concentration of 10 μM.1 It is selective for ATM over PI3K and PIKK in HFF(hTERT) and A-T(hTERT) fibroblasts, respectively. CP 466,722 decreases cell survival in response to ionizing radiation in HeLa cells. It is also cytotoxic to MCF-7 and SKBr-3 breast cancer cells (IC50s = 16.92 and 12.78 μM, respectively).1 | [Uses]
CP466722 is a competetive, reversible inhbitor of Ataxia telangiectasia (A-T) mutated (ATM) kinase | [Definition]
ChEBI: 2-(6,7-dimethoxy-4-quinazolinyl)-5-(2-pyridinyl)-1,2,4-triazol-3-amine is a member of quinazolines. | [target]
ATM | [References]
[1]. guo, k., et al., development of a cell-based, high-throughput screening assay for atm kinase inhibitors. j biomol screen, 2014. 19(4): p. 538-46.
[2]. nadkarni, a., et al., atm inhibitor ku-55933 increases the tmz responsiveness of only inherently tmz sensitive gbm cells. j neurooncol, 2012. 110(3): p. 349-57.
[3]. rainey, m.d., et al., transient inhibition of atm kinase is sufficient to enhance cellular sensitivity to ionizing radiation. cancer res, 2008. 68(18): p. 7466-74. |
|
|