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110429-45-3

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110429-45-3 Structure

110429-45-3 Structure
IdentificationBack Directory
[Name]

Triethylene Glycol 2-Bromoethyl Methyl Ether
[CAS]

110429-45-3
[Synonyms]

mPEG4-Br
m-PEG4-bromo
m-PEG4-bromide
Br-(CH2CH2O)4-Me
Bromo-PEG4-methoxy
Methyl-PEG4-bromide
1-Bromo-3,6,9,12-tetraoxatridecane
13-Bromo-2,5,8,11-tetraoxatridecane
2,5,8,11-Tetraoxatridecane, 13-bromo-
Triethylene Glycol 2-Bromoethyl Methyl Ether
2-[2-[2-(2-Methoxyethoxy)ethoxy]ethoxy]ethyl Bromide
2-[2-[2-(2-Methoxyethoxy)ethoxy]ethoxy]ethyl Bromide 1-Bromo-3,6,9,12-tetraoxatridecane
[Molecular Formula]

C9H19BrO4
[MDL Number]

MFCD12545963
[MOL File]

110429-45-3.mol
[Molecular Weight]

271.149
Chemical PropertiesBack Directory
[Boiling point ]

296.3±25.0 °C(Predicted)
[density ]

1.256±0.06 g/cm3(Predicted)
[refractive index ]

1.4620 to 1.4660
[storage temp. ]

2-8°C
[form ]

clear liquid
[color ]

White to Yellow to Green
[CAS DataBase Reference]

110429-45-3
Safety DataBack Directory
[HS Code ]

2909.19.6000
Hazard InformationBack Directory
[Description]

m-PEG4-bromide is a PEG linker containing a bromide group. The bromide (Br) is a very good leaving group for nucleophilic substitution reactions. The hydrophilic PEG spacer increases solubility in aqueous media.
[Biological Activity]

Triethylene Glycol 2-Bromoethyl Methyl Ether is a cleavable ADC linker for the synthesis of antibody drug conjugates (ADCs) of trastuzumab (HY-P9907). It was placed distal to the monomethyl auristatin E (MMAE) payload to generate ADCs with altered hydrophilicity, antigen binding and in vitro potency. Tetraethylene glycol monotosylate can also be used as a linker of PROTAC, which can be used for the synthesis of PROTAC.
[in vitro]

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

[target]

Cleavable

PEGs

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