| Identification | Back Directory | [Name]
EGT1442 | [CAS]
1118567-05-7 | [Synonyms]
CS-250
THR1442
EGT1442
CS-2165
THR-1442
THR 1442
EGT0001442
EGT-0001442
EGT 0001442
Bexagliflozin
Bexagliflozin3
Bexagliflozin，EGT1442
Bexagliflozin (THR1442)
EGT1442(Bexagliflozin,THR1442)
Bexagliflozin(THR1442,EGT1442)|
EGT1442; THR1442; EGT0001442; EGT-1442; THR-1442; EGT-0001442; EGT 1442; THR 1442; EGT 0001442
(1S)-1,5-Anhydro-1-C-[4-chloro-3-[[4-[2-(cyclopropyloxy)ethoxy]phenyl]methyl]phenyl]-D-glucitol
D-Glucitol, 1,5-anhydro-1-C-[4-chloro-3-[[4-[2-(cyclopropyloxy)ethoxy]phenyl]methyl]phenyl]-, (1S)-
BEXAGLIFLOZIN;EGT-1442;THR1442;EGT0001442;EGT-1442;THR-1442;EGT-0001442;EGT 1442;THR 1442;EGT 0001442 | [EINECS(EC#)]
257-874-6 | [Molecular Formula]
C24H29ClO7 | [MDL Number]
MFCD28100944 | [MOL File]
1118567-05-7.mol | [Molecular Weight]
464.94 |
| Chemical Properties | Back Directory | [Boiling point ]
671.0±55.0 °C(Predicted) | [density ]
1.41 | [storage temp. ]
Store at -20°C | [solubility ]
DMSO:100.0(Max Conc. mg/mL);215.08(Max Conc. mM) | [form ]
A crystalline solid | [pka]
13.23±0.70(Predicted) | [InChIKey]
BTCRKOKVYTVOLU-IZSIRFNDNA-N | [SMILES]
[C@H]1(C2C=C(CC3C=CC(OCCOC4CC4)=CC=3)C(Cl)=CC=2)[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 |&1:0,22,24,26,28,r| |
| Hazard Information | Back Directory | [Description]
EGT-1442 is a potent, selective sodium glucose co-transporter 2 (SGLT2) inhibitor with IC50 values of 5.6 μM and 2 nM for human SGLT1 and SGLT2, respectively. It produces a stable urinary excretion of glucose in rats and dogs with ED50 values of 0.38 and 0.09 mg/kg, respectively, and reduces HbA(1c) and blood glucose in db/db mice in a concentration dependent manner. | [Uses]
Bexagliflozin, also known as EGT1442, is a potent and selective SGLT2 inhibitor, attenuates blood glucose and HbA(1c) levels in db/db mice and prolongs the survival of stroke-prone rats. EGT1442 showed favorable properties both in vitro and in vivo and could be beneficial to the management of type 2 diabetic patients. |
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