| Identification | Back Directory | [Name]
ANILERIDINE HYDROCHLORIDE CII (250 MG) | [CAS]
126-12-5 | [Synonyms]
mk89
aldine
apodol
D02942
Leritine (tn)
leritinedihydrochloride
anileridinedihydrochloride
Anileridine hydrochloride (usp)
ANILERIDINE HYDROCHLORIDE CII (250 MG)
Anileridine Hydrochloride CII (1036008)
ethyl1-(4-aminophenethyl)-4-phenylisonipecotatedihydrochloride
isonipecoticacid,1-(p-aminophenyl)-4-phenyl-,ethylester,dihydrochloride
1-(p-aminophenethyl)-4-phenylisonipecoticacid,ethylester,dihydrochloride
1-(p-aminophenethyl)-4-phenylpiperidine-4-carboxylicacidethylesterhydroch
n-(beta-(p-aminophenyl)ethyl)-4-phenyl-4-carbethoxypiperidinehydrochloride
ethyl 1-[2-(4-aminophenyl)ethyl]-4-phenylpiperidine-4-carboxylate dihydrochloride | [EINECS(EC#)]
204-770-0 | [Molecular Formula]
C22H30Cl2N2O2 | [MOL File]
126-12-5.mol | [Molecular Weight]
425.392 |
| Safety Data | Back Directory | [RIDADR ]
1544 | [HazardClass ]
6.1(b) | [PackingGroup ]
III | [HS Code ]
2933330000 | [Toxicity]
mouse,LD50,intraperitoneal,80mg/kg (80mg/kg),Journal of Pharmacology and Experimental Therapeutics. Vol. 119, Pg. 26, 1957. |
| Hazard Information | Back Directory | [Originator]
Leritine HCl,Merck Sharp and
Dohme,US,1958 | [Uses]
Analgesic (narcotic). | [Definition]
ChEBI: Anileridine dihydrochloride is a hydrochloride salt prepared from anileridine and 2 equivalents of hydrogen chloride. It has a role as an opioid analgesic. It contains an anileridine(2+). | [Manufacturing Process]
A mixture of 7.8 grams (0.05 mol) of β-(p-aminophenyl)ethyl chloride
hydrochloride, 12.5 grams (0.025 mol) of 4-phenyl-4-carboethoxypiperidine
carbonate, 10.5 grams (0.125 mol) sodium bicarbonate, and 100 cc of
anhydrous ethanol are mixed, stirred and heated under reflux for a period of
approximately 40 hours and then concentrated in vacuum to dryness. The
residual material is triturated with 50 cc of water, decanted, washed by
decantation with an additional 50 cc of water, and then dried in vacuum to
give N-[β-(p-aminophenyl)ethyl]-4-phenyl-4-carboethoxypiperidine.
The N-[β-(p-aminophenyl)ethyl]-4-phenyl-4-carboethoxypiperidine is dissolved
in 50 cc of hot anhydrous ethanol, an excess (about 20 cc) of 20% alcoholic
hydrochloric acid solution is added; upon scratching the side of the container
crystals form. One hundred cubic centimeters of ether are then added to the
mixture, the ethereal mixture is cooled, and the crystalline material which
precipitates is recovered by filtration, washed with ether, and dried to give
12.7 grams of N-[β-(p-aminophenyl)ethyl]-4-phenyl-4-carboethoxypiperidine
dihydrochloride which can be further purified by recrystallization from ethanol
or methanal to give substantially pure material; MP 275-277°C. | [Brand name]
Leritine (Merck). | [Therapeutic Function]
Narcotic analgesic |
|