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1351373-50-6

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1351373-50-6 Structure

1351373-50-6 Structure
IdentificationBack Directory
[Name]

Bis-Propargyl-PEG13
[CAS]

1351373-50-6
[Synonyms]

1351373-50-6
CAS_1351373-50-6
Bis-Propargyl-PEG13
Bis-propargyl-PEG12
4,7,10,13,16,19,22,25,28,31,34,37,40-Tridecaoxatritetraconta-1,42-diyne
[Molecular Formula]

C30H54O13
[MDL Number]

MFCD28334510
[MOL File]

1351373-50-6.mol
[Molecular Weight]

622.74
Chemical PropertiesBack Directory
[solubility ]

Soluble in Water, DMSO, DMF, DCM
Hazard InformationBack Directory
[Description]

Bis-propargyl-PEG13 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
[in vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
[structure and hydrogen bonding]

Bis-propargyl-PEG13 comprises two propargyl groups which can form triazole linkages with azide-bearing compounds or biomolecules in copper catalyzed Click Chemistry reactions. The hydrophilic PEG units help improve the solubility of the molecule in aqueous media.
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