| Identification | Back Directory | [Name]
T-3775440 hydrochloride | [CAS]
1422535-52-1 | [Synonyms]
T-3775440HCl
T 3775440;T3775440
T-3775440 hydrochloride | [EINECS(EC#)]
604-604-1 | [Molecular Formula]
C18H23ClN4O | [MDL Number]
MFCD31692337 | [MOL File]
1422535-52-1.mol | [Molecular Weight]
346.86 |
| Hazard Information | Back Directory | [Biological Activity]
| Target | Value | LSD1
() | 2.1 nM |
| [Biological Activity]
T-3775440 hydrochloride is an irreversible LSD1 inhibitor. It is highly selective for LSD1 relative to other monoamine oxidases with IC50 of 2.1 nM. | [in vitro]
T-3775440 hydrochloride enhances the transdifferentiation of erythrocytes/megakaryocytes to granule-like monocytes. It disrupts the interaction of LSD1 and GFI1B. AEL (TF-1a, HEL92.1.7) cells and AMKL (CMK11-5, M07e) cells were treated with T-3775440 for 48 hours, which induced cell cycle arrest and apoptosis. In TF-1a and CMK11-5 cells, treatment with T-3775440 increased cells in G1 and sub-G1 phases. | [in vivo]
T-3775440 inhibits tumor growth in a mouse xenograft model of AML. In mice T-3775440 hydrochloride caused a transient decrease in platelets followed by a large rebound. After a single dose, it had no apparent effect on red blood cell counts. T-3775440 hydrochloride also exerted antitumor activity in AEL (HEL 92.1.7) model and AMKL (CMK11-5) model. | [storage]
Store at -20°C |
|
| Company Name: |
BOC Sciences
|
| Tel: |
16314854226 |
| Website: |
www.bocsci.com |
| Company Name: |
DC Chemicals
|
| Tel: |
021-58447131 13564518121 |
| Website: |
https://www.chemicalbook.com/ShowSupplierProductsList927327/0.htm |
|