| Identification | Back Directory | [Name]
2,1,3-Benzoxadiazol-5-aMine, N-(3-chloro-5-fluorophenyl)-4-nitro- | [CAS]
1422955-31-4 | [Synonyms]
HIF-C2
TC-S 7009
HIF-2α-I2
HIF-2 inhibitor 2
TCS 7009,TC S 7009
HIF-2 Antagonist 2
HIF-2α Antagonist 2
HIF Inhibitor VII - Calbiochem
N-(3-Chloro-5-fluorophenyl)-4-nitro-2,1,3-benzoxadiazol-5-amine
2,1,3-Benzoxadiazol-5-aMine, N-(3-chloro-5-fluorophenyl)-4-nitro-
N-(3-Chloro-5-fluorophenyl)-4-nitrobenzo[c][1,2,5]oxadiazol-5-amine | [Molecular Formula]
C12H6ClFN4O3 | [MDL Number]
MFCD25371546 | [MOL File]
1422955-31-4.mol | [Molecular Weight]
308.652 |
| Chemical Properties | Back Directory | [storage temp. ]
room temp | [solubility ]
DMSO: soluble15mg/mL, clear | [form ]
Yellow powder | [color ]
white to beige | [Stability:]
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or DMF may be stored at -20°C for up to 1 month. |
| Hazard Information | Back Directory | [Description]
HIF-2α-I2 (1422955-31-4) is a potent and selective HIF-2α inhibitor, Kd=81 nM.1?Binds to the HIF-2α PAS-B domain2?and interferes with Hif-2α / ARNT heterodimerization reducing target gene expression in a cellular model1. Highly selective for HIF-2α displaying a >60-fold selectivity over HIF-1α.1,2 | [Uses]
N-(3-Chloro-5-fluorophenyl)-4-nitro-2,1,3-benzoxadiazol-5-amine is a HIF-2α inhibitor which inhibits HIF-2α-ARNT heterodimerization by binding to HIF-2α PAS-B domain. It may be used in therapeutic treatment of HIF-2-driven tumors such as renal cell carcinomas. | [storage]
Store at RT | [References]
1) Scheuermann?et al.?(2013),?Allosteric inhibition of hypoxia inducible factor-2 with small molecules; Nat. Chem. Biol.,?9?271
2) Masetti?et al.?(2014),?Protein dynamics of the HIF-2α PAS-B domain upon heterodimerization and ligand binding; PLoS One,?9(4)?e94986
3) Rodgers?et al.?(2013),?Development of inhibitors of the PAS-B domain of the HIF-2α transcription factor; J. Med. Chem.,?56 1739 |
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SPIRO PHARMA
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BOC Sciences
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Energy Chemical
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