ChemicalBook--->CAS DataBase List--->1496552-51-2

1496552-51-2

1496552-51-2 Structure

1496552-51-2 Structure
IdentificationBack Directory
[Name]

Sofosbuvir IMpurity B
[CAS]

1496552-51-2
[Synonyms]

Sofosbuvir IMpurity B
Sofosbuvir impurity K
Sofosbuvir Chloro Analog
Sofosbuvir Chloro Analogue
sofosbuvir impurity Y008005-K
L-Alanine, N-[[P(S),2'R]-2'-chloro-2'-deoxy-2'-methyl-P-phenyl-5'-uridylyl]-, 1-methylethyl ester
(2S)-isopropyl 2-(((((2R,3R,4R,5R)-4-chloro-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)amino)propanoate
(S)-isopropyl 2-(((S)-(((2R,3R,4R,5R)-4-chloro-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)amino)propanoate
[Molecular Formula]

C22H29ClN3O9P
[MOL File]

1496552-51-2.mol
[Molecular Weight]

545.91
Chemical PropertiesBack Directory
[density ]

1.43±0.1 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[solubility ]

Soluble in DMSO
[pka]

9.39±0.10(Predicted)
Hazard InformationBack Directory
[Uses]

Chloro Sofosbuvir is an impurity of Sofosbuvir (P839640); a prodrug that is metabolized to the active antiviral agent 2''-deoxy-2''-α-fluoro-β-C-methyluridine-5''-monophosphate and is currently being investigated in phase 3 clinical trials for the treatment of hepatitis C. Studies have profiled Sofosbuvir as a nucleotide inhibitor of hepatitis C virus, exerting selective inhibitory effects towards HCV NS5B polymerase.
[storage]

Store at -20°C
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