| Identification | Back Directory | [Name]
NU7026 | [CAS]
154447-35-5 | [Synonyms]
CS-595
LY 293646
NU7026, >=98%
NU7026 USP/EP/BP
NU 7026; NU-7026
NU7026;LY293646; NU-7026
2-MORPHOLINO-4H-BENZO[H]CHROMEN-4-ONE
2-(4-Morpholinyl)-4H-naphtho[1,2-b]pyran-4-one
2-(4-Morpholinyl)-4H-naphthol[1,2-b]pyran-4-one
4H-Naphtho[1,2-b]pyran-4-one, 2-(4-morpholinyl)-
DNA-PK Inhibitor II - CAS 154447-35-5 - Calbiochem
2-(4-Morpholinyl)-4H-naphtho[1,2-b]pyran-4-one NU7026 | [Molecular Formula]
C17H15NO3 | [MDL Number]
MFCD06798345 | [MOL File]
154447-35-5.mol | [Molecular Weight]
281.31 |
| Chemical Properties | Back Directory | [Melting point ]
267-269 °C(Solv: methanol (67-56-1); water (7732-18-5)) | [Boiling point ]
459.9±45.0 °C(Predicted) | [density ]
1.330 | [storage temp. ]
2-8°C | [solubility ]
DMSO: 3 mg/mL at 60 °C, soluble
| [form ]
solid
| [pka]
0.49±0.20(Predicted) | [color ]
tan
|
| Hazard Information | Back Directory | [Uses]
DNA-PK Inhibitor II is an antiproliferative agent, and inhibitor of DNA-PK. | [Uses]
NU7026 has been used:
- as a DNA-dependent protein kinase (DNA-PK) inhibitor, to pre-treat colon cancer cell
- in kinase inhibitor experiments for treating zygotes with visible pronuclei post 20 h-human chorionic gonadotropin (hCG)
- to determine its influence on cytotoxicity of dibenzo[def,p]chrysene on HepG2 cells
| [Definition]
ChEBI: 2-(4-morpholinyl)-4-benzo[h][1]benzopyranone is an organooxygen compound and an organic heterotricyclic compound. | [Biological Activity]
ATP-competitive inhibitor of DNA-dependent protein kinase (DNA-PK). Displays selectivity over other PIKK family enzymes (IC 50 values are 0.23, 13.0, > 100 and > 100 μ M for DNA-PK, PI3K, ATM and ATR respectively). Radiosensitizes both proliferating and quiescent mouse embryonic fibroblast cells to IR and inhibits DSB repair. | [Biochem/physiol Actions]
Cell permeable, small molecule benzochromenone inhibitor of DNA-PK (DNA dependent protein kinase). | [storage]
Store at +4°C |
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