| Identification | Back Directory | [Name]
aselacin C | [CAS]
156223-08-4 | [Synonyms]
aselacin C
Glycine, N2-(1,9-dioxo-10,12-octadecadien-1-yl)-D-glutaminyl-L-threonyl-β-alanyl-D-tryptophyl-D-seryl-, (6→2)-lactone | [Molecular Formula]
C46H66N8O11 | [MOL File]
156223-08-4.mol | [Molecular Weight]
907.06 |
| Hazard Information | Back Directory | [Description]
Aselacin C is a cyclic pentapeptolide antagonist of endothelin receptor type A (ETA) and ETB originally isolated from Acremonium.1 It inhibits the binding of endothelin-1 to isolated bovine atrial membranes and porcine cerebral membranes, which endogenously express high levels of ETA and ETB, respectively, with IC50 values of 60 and 80 μg/ml, respectively. | [References]
1. Jackson, M., Burres, N.S., Karwowski, J.P., et al. Aselacins, novel compounds that inhibit binding of endothelin to its receptor. I. The producing organism, fermentation and biological activity J. Antibiot. 47(5),523-527(1994). |
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