| Identification | Back Directory | [Name]
SHU-9119 | [CAS]
168482-23-3 | [Synonyms]
SHU-9119
CHEMBL3422426
SHU9119 (trifluoroacetate salt)
AC-NLE-ASP-HIS-D-2-NAL-ARG-TRP-LYS-NH2
AC-NLE-ASP-HIS-D-2-NAL-H2N-LYS-TRP-ARG
AC-NLE-ASP-HIS-D-NAL(2)-ARG-TRP-LYS-NH2
Ac-Nle-cyclo(-Asp-His-D-2-Nal-Arg-Trp-Lys-NH2)
AC-NLE-CYCLO[(BETA-D)-H-(D-2-NAL)-RW-(EPSILON-K)]-NH2
AC-NLE4-C[ASP5, D-NAL(2)7, LYS10]ALPHA-MSH (4-10)-NH2
AC-NLE-CYCLO(BETA-ASP-HIS-D-2-NAL-ARG-TRP-EPSILON-LYS)-NH2
(AC-NLE4,ASP5,D-2-NAL7,LYS10)-CYCLO-ALPHA-MSH (4-10) AMIDE
Acetyl-(Nle4,Asp5,D-2-Nal7,Lys10)-cyclo-α-MSH (4-10) amide
Acetyl-(Nle4,Asp5,D-2-Nal7,Lys10)-cyclo-a-MSH (4-10) aMide
[ACETYL-NLE4, ASP5, D-2-NAL7, LYS10]-ALPHA-MSH (4-10) AMIDE
AC-[NLE4, ASP5, D-2-NAL7, LYS10]-CYCLO-ALPHA-MSH AMIDE (4-10)
Acetyl-(Nle4,Asp5,D-2-Nal7,Lys10)-cyclo-Alpha-MSH (4-10) amide
Ac-Nle-Asp-His-D-Nal(2)-Arg-Trp-Lys-NH2 (AMide bond Asp5-Lys10)
(Ac-Nle4,Asp5,D-Ala(2-naphthyl)7,Lys10)-cyclo-a-MSH (4-10) amide
Acetyl-(Nle4,Asp5,D-2-Nal7,Lys10)-cyclo-α-MSH (4-10) aMide
SHU9119
AC-NLE-ASP-HIS-D-2'-NAL-ARG-TRP-LYS-NH2, ASP5-LYS10, CYCLIC LACTAM
(AC-NLE4,ASP5,D-ALA(2-NAPHTHYL)7,LYS10)-CYCLO-ALPHA-MSH (4-10) AMIDE
AC-NLE-CYCLO(-ASP-HIS-D-2-NAL-ARG-TRP-LYS-NH2) TRIFLUOROACETATE SALT
AC-NLE-CYCLO(-BETA-ASP-HIS-D-ALA(2-NAPHTHYL)-ARG-TRP-EPSILON-LYS-NH2)
Acetyl-(Nle4,Asp5,D-2-Nal7,Lys10)-cyclo-α-MSH (4-10) amide trifluoroacetate salt
(ACETYL-NLE4,ASP5,D-2-NAL7,LYS10)-CYCLO-ALPHA-MSH (4-10) AMIDE TRIFLUOROACETATE SALT
[ACETYL-NLE4, ASP5, D-2-NAL7, LYS10]-ALPHA-MELANOCYTE STIMULATING HORMONE (4-10) AMIDE
[N-ACETYL-NLE4,ASP5,D-2'-NAL7,LYS10]-ALPHA-MSH (4-10) AMIDE, ASP5-LYS10, CYCLIC LACTAM
Acetyl-[Nle4, Asp5, D-2-Nal7, Lys10]-cyclo-α-Melanocyte Stimulating Hormone Amide Fragment 4-10
L-Lysinamide, N-acetyl-L-norleucyl-L-α-aspartyl-L-histidyl-3-(2-naphthalenyl)-D-alanyl-L-arginyl-L-tryptophyl-, (2→7)-lactam | [Molecular Formula]
C54H71N15O9 | [MDL Number]
MFCD01631255 | [MOL File]
168482-23-3.mol | [Molecular Weight]
1074.24 |
| Chemical Properties | Back Directory | [density ]
1.43±0.1 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
H2O : 20 mg/mL (18.62 mM; Need ultrasonic) | [form ]
Powder | [pka]
13.00±0.70(Predicted) | [Water Solubility ]
Soluble to 0.20 mg/ml in water | [Sequence]
Ac-Nle-Asp-His-D-Nal-Arg-Trp-Lys-NH2(Chemical Bridge Asp2-Lys7) |
| Hazard Information | Back Directory | [Description]
SHU9119 is an agonist of melanocortin receptor 1 (MC1R) and antagonist of MC4R (IC50s = 1.2 and 2.9 nM, respectively, for displacement of melanocortin). It induces cAMP formation in HEK293 cells expressing human MC1R (EC50 = 1.11 nM), but inhibits cAMP formation in cells expressing human MC4R. In rats, SHU9119 (24 nmol, i.c.v. per day for seven days) increases food intake, body weight, fat mass, and lean mass, with concomitant increases in blood glucose, insulin, and leptin levels via disrupted melanocortin signaling. Similarly, mice treated with SHU9119 (5 nmol/day, i.c.v.) exhibit food intake-independent increases in body weight and fat mass consequent to MC4R inhibition and subsequent brown adipose tissue dysfunction. | [storage]
Store at -20°C |
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