| Identification | Back Directory | [Name]
NSC 55712 | [CAS]
2076-91-7 | [Synonyms]
R 55
NSC 55712
TPT-260 2HCl
TPT-260 , NSC55712
TPT-260 2HCl(NSC55712)
TPT-260 (hydrochloride)
TPU-260 Dihydrochloride
NSC55712 Dihydrochloride
TPT-260 (Dihydrochloride)
TPT-260 Dihydrochloride, >=98%
TPT-260 (Dihydrochloride), NSC55712
thiene-2,5-diyldimethanediyl dicarbamimidothioate
THIOPHENE-2,5-DIYLBIS(METHYLENE) DICARBAMIMIDOTHIOATE.2HCL
Thiophene-2,5-diylbis(methylene) dicarbamimidothioate dihydrochloride
Carbamimidothioic acid 2,5-thiophenediylbis(methylene) ester dihydrochloride
Carbamimidothioic acid,C,C'-[2,5-thiophenediylbis(methylene)] ester, hydrochloride (1:2)
[({5-[(carbamimidoylsulfanyl)methyl]thiophen-2-yl}methyl)sulfanyl]methanimidamide dihydrochloride
NSC55712; TPT260 DIHYDROCHLORIDE; TPT 260 DIHYDROCHLORIDE; TPU-260 DIHYDROCHLORIDE;NSC-55712;NSC 55712
NSC 55712 Carbamimidothioic acid 2,5-thiophenediylbis(methylene) ester dihydrochloride | [Molecular Formula]
C8H14Cl2N4S3 | [MDL Number]
MFCD25976641 | [MOL File]
2076-91-7.mol | [Molecular Weight]
333.325 |
| Chemical Properties | Back Directory | [Melting point ]
210℃ (Decomposition) | [storage temp. ]
Keep in dark place,Inert atmosphere,Store in freezer, under -20°C | [solubility ]
DMSO:62.5(Max Conc. mg/mL);240.02(Max Conc. mM) | [form ]
A crystalline solid |
| Hazard Information | Back Directory | [Uses]
Retromers are multiprotein complexes responsible for trafficking cargo out of endosomes. This is an important function that, in the case of amyloid-precursor protein (APP), is neuroprotective by preventing APP from being cleaved into Alzheimer’s disease-inducing fragments via the endosome. TPT-260 is a thiophene thiourea derivative that acts as a chaperone to stabilize the retromer complex against thermal denaturation (Kd = ~5 μM). In cultured hippocampal neurons, TPT-260 dose-dependently increases the level of retromer proteins, redirects APP from the endosome, and reduces the formation of pathogenic APP.[Cayman Chemical] | [storage]
Store at -20°C |
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| Company Name: |
D&C Chemicals
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| Tel: |
+86-21-58447131 |
| Website: |
www.chemicalbook.com/ShowSupplierProductsList16963/0.htm |
| Company Name: |
SPIRO PHARMA
|
| Tel: |
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| Website: |
www.spiropharma.com.cn |
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