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2133832-83-2

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2133832-83-2 Structure

2133832-83-2 Structure
IdentificationBack Directory
[Name]

R-IMPP
[CAS]

2133832-83-2
[Synonyms]

R-IMPP
Benzenepropanamide, N-1-isoquinolinyl-4-methoxy-N-(3R)-3-piperidinyl-
[Molecular Formula]

C24H27N3O2
[MDL Number]

MFCD31544323
[MOL File]

2133832-83-2.mol
[Molecular Weight]

389.49
Chemical PropertiesBack Directory
[Boiling point ]

594.4±50.0 °C(Predicted)
[density ]

1.186±0.06 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[solubility ]

DMF: 1 mg/ml; DMSO: 10 mg/ml
[form ]

A crystalline solid
[pka]

9.14±0.10(Predicted)
Hazard InformationBack Directory
[Description]

(R)-IMPP is a cell-permeable inhibitor of the secretion of proprotein convertase subtilisin/kexin type 9 (PCSK9; IC50 = 4.8 μM). It promotes the uptake of LDL cholesterol in hepatoma cells by increasing LDL receptor levels. (R)-IMPP apparently impairs PCSK9 secretion by causing transcript-dependent inhibition of PCSK9 translation.
[storage]

Store at -20°C
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