| Identification | Back Directory | [Name]
oxophenarsine | [CAS]
306-12-7 | [Synonyms]
Oxarsan
Phenarsen
Brn 3235865
oxophenarsine
Einecs 206-178-8
2-Amino-4-arsenosophenol
Phenol, 2-amino-4-arsenoso-
538-03-4 (Mono-hydrochloride)
3-Amino-4-hydroxyphenylarsinoxide
63951-03-1 (Mono-hydrochloride salt)
(3-Amino-4-hydroxyphenyl)arsenous acid | [EINECS(EC#)]
206-178-8 | [Molecular Formula]
C6H6AsNO2 | [MOL File]
306-12-7.mol | [Molecular Weight]
199.04 |
| Chemical Properties | Back Directory | [Melting point ]
133°C (rough estimate) | [Boiling point ]
117.4°C | [form ]
solid | [color ]
Bright-yellow deliquescent powder or white crystals |
| Hazard Information | Back Directory | [Brand name]
Mapharsen (Parke-Davis). | [Definition]
ChEBI: Oxophenarsine is a substituted aniline. | [Industrial uses]
Palladium dissolves in hot oxidising acids. Palladium is used as a hydrogenation catalyst, for H2/D2/T2separation and purification as well as a catalyst
in the Wacker process. The Wacker process, which facilitates the oxidation of ethylene to acetaldehyde, was
the first organopalladium reaction that was applied on an industrial scale. | [Enzyme inhibitor]
This sulfhydryl-reactive arsenical (FW = 199.04 g/mol; CAS 306-12-7), variously named Mapharsen, Ehrlich-5, oxyphenarsine, oxarsan, arsinoxide, 3-amino-4-hydroxybenzenearsenoxide, and 2-amino-4-arsenosophenol, was originally developed by Nobelist Paul Ehrlich as an anti-syphilis drug. (Note: do not confuse this compound with oxophenylarsine, also known phenylarsine oxide). It is now used as an antiprotozomal agent, particularly against Trypanosoma. Oxophenarsine is typically supplied as the hydrochloride (FW = 235.50 g/mol) and is readily soluble in water. (See also Dichlorophenarsine) Target(s): acetyl-CoA acyltransferase; actomyosin ATPase; aldehyde dehydrogenase; alkaline phosphatase; asparagine synthetase; ATPase, rat brain; ATPase, trypanosomal; cathepsin; cholinesterase; deoxyribonuclease; diisopropylfluorophosphatase; γ-glutamyl hydrolase, or pteroylglutamate conjugase; glyceraldehyde-3-phosphate dehydrogenase; a-glycerophosphate oxidase; hexokinase; myosin ATPase; pyrophosphatase; pyruvate decarboxylase; pyruvate oxidase; ribose-5-phosphate isomerase; succinate dehydrogenase; succinate oxidase; urease. |
| Safety Data | Back Directory | [Safety Profile]
Poison by ingestion and intravenous routes. When heated to decomposition it emits toxic fumes of NOx and As | [Toxicity]
LDLo orl-mus: 150 mg/kg JPETAB 76,358,42 |
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