| Identification | Back Directory | [Name]
DANSYL ETHYLENEDIAMINE | [CAS]
35060-08-3 | [Synonyms]
DNSEDA
NSC 666752
DANSYL ETHYLENEDIAMINE
N-Dansylethylenediamine
(2-AMINOETHYL)-DANSYLAMIDE
N-(2-Aminoethyl)dansylamide
2-(5-DiMethylaMino-1-naphthalenesulfonaMido)ethylaMine
N-(2-AMinoethyl)-5-(diMethylaMino)-1-naphthalenesulfonaMide
5-DIMETHYLAMINONAPHTHALENE-1-(N-(2-AMINOETHYL))-SULFONAMIDE
Dansyl ethylenediaMine [5-DiMethylaMinonaphthalene-1-(N-(2-aMinoethyl))sulfonaMide] | [Molecular Formula]
C14H19N3O2S | [MDL Number]
MFCD00467523 | [MOL File]
35060-08-3.mol | [Molecular Weight]
293.38 |
| Chemical Properties | Back Directory | [Appearance]
Yellow Solid | [Melting point ]
145-146°C | [Boiling point ]
470.2±55.0 °C(Predicted) | [density ]
1.262±0.06 g/cm3(Predicted) | [storage temp. ]
-20?C Freezer | [solubility ]
methanol: soluble1mg/mL, clear, slightly yellow to deep yellow | [form ]
Solid | [pka]
11.30±0.50(Predicted) | [color ]
Light Yellow | [BRN ]
2817535 |
| Hazard Information | Back Directory | [Chemical Properties]
Yellow Solid | [Uses]
A fluorescent reagent | [Description]
Dansyl ethylenediamine is a lipophilic fluorophore that can be coupled to coarboxylic acids of proteins and other water-soluble polymers. The primary aliphatic amine of dansyl ethylenediamine can be reversibly coupled to aldehydes and ketones to form a Schiff base, which can be reduced to a generate stable amine derivative by sodium borohydride (NaBH4) or sodium cyanoborohydride (NaCNH3). Spectral data: λex=335nm, λem=525nm in methanol. Dansyl ethylenediamine has also shown to inhibit human renal dipeptidase (hrDP) irreversibly in a time-dependent manner. | [References]
[1] YUKI INOUE. Fluorescent molecularly imprinted polymer thin films for specific protein detection prepared with dansyl ethylenediamine-conjugated O-acryloyl l-hydroxyproline[J]. Biosensors and Bioelectronics, 2013. DOI:10.1016/j.bios.2013.03.005.
[2] ADACHIH. Importance of Glu-125 in the catalytic activity of human renal dipeptidase.[J]. Biochimica et biophysica acta, 1993. DOI:10.1016/0167-4838(93)90276-w.
[3] MALLAMPATI S, AERSCHOT A V, HOOGMARTENS J, et al. Analysis of dideoxyadenosine triphosphate by CE with fluorescence detection. I. Derivatization through the phosphate group[J]. ELECTROPHORESIS, 2007, 28. DOI:10.1002/elps.200700234.
[4] DUDLEY R W, SLOTTERBECK B D, MCINERNEY M F, et al. Fatty acylation enhances cellular localization of dansylated phenylalanines[J]. Molecular and Cellular Biochemistry, 2010, 346: 81-87. DOI:10.1007/s11010-010-0593-4. |
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