| Identification | Back Directory | [Name]
9,10-DIHYDRO-9,10[1',2']-BENZENOANTHRACENE-1,4-DIONE | [CAS]
3519-82-2 | [Synonyms]
INCA-6
Nsc25996
NFAT Activation Inhibitor III
INCA-6 NFAT Activation Inhibitor III
9,10-[1,2]benzenoanthracene-13,16(9H,10H)-dione
9,10-[1,2]Benzeno-9,10-dihydro-1,4-anthraquinone
9,10-Dihydro-9,10-[1,2]benzeno-1,4-anthraquinone
9,10-[1,2]Benzeno-9,10-dihydroanthracene-1,4-dione
9,10-DIHYDRO-9,10[1',2']-BENZENOANTHRACENE-1,4-DIONE
9,10[1',2']-Benzenoanthracene-1,4-dione, 9,10-dihydro-
1,4,9,10-Tetrahydro-9,10-[1,2]benzenoanthracene-1,4-dione
9,10-[1,2]Benzeno-1,4,9,10-tetrahydroanthracene-1,4-dione | [Molecular Formula]
C20H12O2 | [MDL Number]
MFCD00226933 | [MOL File]
3519-82-2.mol | [Molecular Weight]
284.31 |
| Hazard Information | Back Directory | [Description]
NFAT activation inhibitor III is a cell-permeant inhibitor of signaling through nuclear factor of activated T cells (NFAT). It binds the substrate recognition site of the phosphatase calcineurin (Kd = 0.8 μM), preventing it from binding and dephosphorylating NFAT. NFAT activation inhibitor III blocks the nuclear import of NFAT in T cells stimulated with ionomycin . It prevents the induced expression of cytokine mRNAs in T cells stimulated with phorbol ester and ionomycin. | [Uses]
INCA 6 inhibits nuclear factor of activated T cells (NFAT) dephosphorylation and nuclear import, which in turn, interferes with downstream targets of NFAT including induction of cytokine mRNAs. | [Definition]
ChEBI: LSM-2729 is an anthraquinone. | [General Description]
A cell-permeable, potent, and selective inhibitor of Calcineurin-NFAT (Nuclear Factor of Activated T cells) signaling. Binds to calcineurin with high affinity (Kd = 800 nM), disrupts its interaction with NFAT, and completely blocks calcineurin-dependent NFAT dephosphorylation, nuclear import (~40 μM in C1.7W2 T cells), and induction of NFAT-targeted cytokine mRNAs. Unlike CsA (Cat. No. 239835) and FK506, INCA-6 does not affect calcineurin activity or its downstream signaling. | [Biological Activity]
Inhibitor of interaction between calcineurin and its substrate nuclear factor of activated T cells (NFAT); blocks at the substrate recognition site but not at the catalytic site (K d = 0.8 mM). Inhibits NFAT dephosphorylation and nuclear import. Also prevents induction of cytokine mRNAs that are downstream targets of NFAT. | [Biochem/physiol Actions]
Cell permeable: yes | [storage]
Store at -20°C |
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| Company Name: |
Spectrum Chemical Manufacturing Corp.
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| Tel: |
021-021-021-67601398-809-809-809 15221380277 |
| Website: |
www.spectrumchemical.com/oa_html/index.jsp?minisite=10020&respid=22372&language=us |
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