ChemicalBook--->CAS DataBase List--->383365-04-6

383365-04-6

383365-04-6 Structure

383365-04-6 Structure
IdentificationBack Directory
[Name]

Tenofovir Related Compound 6
[CAS]

383365-04-6
[Synonyms]

TAF-IM-A2
TAF Impurity E
Tenofovir Impurity 6
Tenofovir Impurity 48
Tenofovir Impurity 6-d6
enofovir Related Compound 6
Tenofovir Related Compound 6
Tenofovir Alafenamide Impurity 3
Tenofovir Alafenamide Impurity E
Tenofovir Alafenamide (R-Phosphine)
Tenofovir Alafenamide Diasteromer-1
Tenofovir Alafenamide Impurity 13 Monomer
9-[(R)-2-[[(S)-[[(S)-1-(isopropoxycarbonyl)ethyl]amino]-phenoxyphosphinyl]methoxy]propyl]adenine
isopropyl (((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)(phenoxy)phosphoryl)-L-alaninate
N-[(R)-[[(1R)-2-(6-Amino-9H-purin-9-yl)-1-methylethoxy]methyl]phenoxyphosphinyl]-L-alanine 1-Methylethyl Ester
L-Alanine,N-[(R)-[[(1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]phenoxyphosphinyl]-, 1-methylethyl ester
(S)-isopropyl 2-(((R)-((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)(phenoxy)phosphoryl)amino)propanoate
[Molecular Formula]

C21H29N6O5P
[MDL Number]

MFCD23704939
[MOL File]

383365-04-6.mol
[Molecular Weight]

476.47
Chemical PropertiesBack Directory
[Boiling point ]

640.4±65.0 °C(Predicted)
[density ]

1.39±0.1 g/cm3(Predicted)
[pka]

4.21±0.10(Predicted)
Hazard InformationBack Directory
[Uses]

(S)-Isopropyl 2-(((R)-((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)(phenoxy)phosphoryl)amino)propanoate is an isomer of Tenofovir Alafenamide (T018555), is a prodrug of Tenofovir (T018500).
[Definition]

ChEBI: Tenofovir alafenamide is an L-alanine derivative that is isopropyl L-alaninate in which one of the amino hydrogens is replaced by an (S)-({[(2R)-1-(6-amino-9H-purin-9-yl)propan-2-yl]oxy}methyl)(phenoxy)phosphoryl group. A prodrug for tenofovir, it is used (as the fumarate salt) in combination therapy for the treatment of HIV-1 infection. It has a role as an antiviral drug, a HIV-1 reverse transcriptase inhibitor and a prodrug. It is a L-alanine derivative, a phosphoramidate ester, an ether, a member of 6-aminopurines and an isopropyl ester. It is functionally related to an adenine. It is a conjugate base of a tenofovir alafenamide(1+).
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