| Identification | Back Directory | [Name]
12(S)-HHT | [CAS]
54397-84-1 | [Synonyms]
12-HHT
12-HHTRE
12(S)-HHT
12(S)-HHTRE
12(S)-HHTrE (12(S)-HHT)
KUKJHGXXZWHSBG-WBGSEQOASA-N
12(S)-HHTrE Lipid Maps MS Standard
12-HYDROXY-HEPTA- DECATRIENOIC ACID
12(S)-HYDROXYHEPTADECA-5Z,8E,10E-TRIENOIC ACID
12(S)-HYDROXY-(5Z,8E,10E)-HEPTADECATRIENOIC ACID
12(S)-hydroxy-5(Z),8(E),10(E)-*heptadecatrienoic
12(S)-HYDROXY-5(Z),8(E),10(E)-*HEPTADECA TRIENOIC AC
(12S,5Z,8E,10E)-12-Hydroxy-5,8,10-heptadecatrienoic acid
(5Z,8E,10E,12S)-12-Hydroxy-5,8,10-heptadecatrienoic acid
5,8,10-Heptadecatrienoic acid, 12-hydroxy-, (5Z,8E,10E,12S)- | [Molecular Formula]
C17H28O3 | [MDL Number]
MFCD00057833 | [MOL File]
54397-84-1.mol | [Molecular Weight]
280.4 |
| Chemical Properties | Back Directory | [Boiling point ]
451.8±45.0 °C(Predicted) | [density ]
0.992±0.06 g/cm3(Predicted) | [storage temp. ]
−20°C | [solubility ]
0.1 M Na2CO3: 2 mg/ml; DMF: Miscible; DMSO: Miscible; Ethanol: Miscible; PBS pH 7.2: 0.8 mg/ml | [form ]
ethanol solution | [pka]
4.75±0.10(Predicted) |
| Hazard Information | Back Directory | [Uses]
12(S)-HHTrE is a metabolite of arachidonic acid (A765000), which is an essential fatty acid and a precursor in the biosynthesis of prostaglandins, thromboxanes, and leukotrienes. Arachidonic Acid occurs in liver, brain, glandular organs, and depot fats of animals, in small amounts in human depot fats, and Arachidonic Acid is also a constituent of animal phosphatides. | [Uses]
12(S)-HHTrE is an unusual product of the cyclooxygenase (COX) pathway and one of the primary arachidonic acid metabolites of the human platelet. It is biosynthesized by thromboxane synthase (TX synthase) from prostaglandin H2 (PGH2) concurrently with TXA2. The biological role of 12(S)-HHTrE is uncertain. It is avidly oxidized to 12-oxoHTrE by porcine 15-hydroxy PGDH. | [Definition]
ChEBI: A trienoic fatty acid that consists of (5Z,8E,10E)-heptadeca-5,8,10-trienoic acid bearing an additional 12S-hydroxy substituent. | [storage]
Store at -20°C |
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