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56296-18-5

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56296-18-5 Structure

56296-18-5 Structure
IdentificationBack Directory
[Name]

11-Piperazinyldibenzo[b,e][1,4]diazepine
[CAS]

56296-18-5
[Synonyms]

DREADD agonist 1
DREADD Agonist 21
11-Piperazinyldibenzo[b,e][1,4]diazepine
11-(1-Piperazinyl)-5H-dibenzo[b,e][1,4]diazepine
5H-Dibenzo[b,e][1,4]diazepine, 11-(1-piperazinyl)-
[Molecular Formula]

C17H18N4
[MDL Number]

MFCD25121806
[MOL File]

56296-18-5.mol
[Molecular Weight]

278.35
Chemical PropertiesBack Directory
[Boiling point ]

470.1±55.0 °C(Predicted)
[density ]

1.28±0.1 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[solubility ]

DMSO:PBS (pH 7.2) (1:1):0.5(Max Conc. mg/mL);1.8(Max Conc. mM)
Ethanol:29.61(Max Conc. mg/mL);106.39(Max Conc. mM)
[form ]

A crystalline solid
[pka]

8.56±0.10(Predicted)
[color ]

Yellow
Safety DataBack Directory
[Symbol(GHS) ]


GHS07
[Signal word ]

Warning
[Hazard statements ]

H302-H315-H319-H335
[Precautionary statements ]

P261-P280-P301+P312-P302+P352-P305+P351+P338
Hazard InformationBack Directory
[Description]

DREADD agonist 21 activates hM3Dq (EC50 = 1.7 nM), a designer receptor exclusively activated by designer drugs (DREADD) derived from the human muscarinic acetylcholine M3 receptor. It does not agonize the hM3 receptor and displays relatively weaker binding affinities for serotonin 5-HT2A, 5-HT2C, α1A-adrenergic, and histamine H1 receptors (Kis = 66, 170, 280, and 6 nM, respectively).
[Uses]

DREADD agonist 21 is an agonist of hM3Dq, a designer receptor exclusively activated by designer drugs (DREADD). It preferentially binds hM3Dq?DREADDs over endogenous hM3?receptors.
[storage]

Room temperature
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