| Identification | Back Directory | [Name]
1'-HYDROXYMIDAZOLAM | [CAS]
59468-90-5 | [Synonyms]
1-Oh-mdz
RO 21-6347
A-HYDROXYMIDAZOLAM
1Hydroxymidazolame
α-Hydroxymidazolam
1-HYDROXY MIDAZOLAM
1'-HYDROXYMIDAZOLAM
Midazolam Impurity 1
ALPHA-HYDROXYMIDAZOLAM
alpha-Hydroxymidazolame
1-hydroxymethylmidazolam
α-Hydroxymidazolam solution
1'-Hydroxy MidazolaM (100 μg/ML in Methanol)
4H-Imidazo1,5-a1,4benzodiazepine-1-methanol, 8-chloro-6-(2-fluorophenyl)-
8-Chloro-6-(2-fluorophenyl)-4H-imidazo[1,5-a][1,4]benzodiazepine-1-methanol
8-CHLORO-6-(2-FLUOROPHENYL)-1-HYDROXYMETHYL-4H-IMIDAZO[1,5A][1,4]BENZODIAZEPINE | [EINECS(EC#)]
200-659-6 | [Molecular Formula]
C18H13ClFN3O | [MDL Number]
MFCD00871458 | [MOL File]
59468-90-5.mol | [Molecular Weight]
341.77 |
| Chemical Properties | Back Directory | [Appearance]
White Solid | [Melting point ]
264-266oC | [Boiling point ]
540.6±60.0 °C(Predicted) | [density ]
1.43±0.1 g/cm3(Predicted) | [Fp ]
9℃ | [storage temp. ]
2-8°C
| [solubility ]
DMF: 2 mg/ml; DMSO: 1 mg/ml | [form ]
A crystalline solid | [pka]
13.59±0.10(Predicted) | [color ]
white or off-white
|
| Hazard Information | Back Directory | [Chemical Properties]
White Solid | [Uses]
A metabolite of Midazolam (M343000). | [Uses]
CYP3A4 metabolite of midazolam | [Description]
1''-hydroxy Midazolam is the major metabolite of the anesthetic, midazolam. It is produced rapidly by the actions of hepatic cytochrome P450 3A and has been shown to be equipotent to midazolam. | [Definition]
ChEBI: 1-hydroxymidazolam is an imidazobenzodiazepine that is midazolam in which one of the hydrogens of the methyl group is substituted by a hydroxy group. It is the major metabolite of the anesthetic, midazolam. It has a role as a drug metabolite, a human blood serum metabolite and a human urinary metabolite. It is an imidazobenzodiazepine, an organochlorine compound, a member of monofluorobenzenes and an aromatic primary alcohol. It is functionally related to a midazolam. | [storage]
Store at -20°C |
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