ChemicalBook--->CAS DataBase List--->60084-10-8

60084-10-8

60084-10-8 Structure

60084-10-8 Structure
IdentificationBack Directory
[Name]

Tiazofurine
[CAS]

60084-10-8
[Synonyms]

TCAR
CI 909
Riboxamide
NSC-286193
tiazofurin
Aids014479
Aids-014479
NSC-286-193
Tiazofurine
2-b-D-Ribofuranosyl-4-thiazolecarboxaMide
2-β-D-Ribofuranosyl-4-thiazolecarboxaMide
2-β-D-Ribofuranosylthiazole-4-carboxaMide
4-Thiazolecarboxamide, 2-β-D-ribofuranosyl-
2-.beta.-D-Ribofuranosyl-4-thiazolecarboxamide
[Molecular Formula]

C9H12N2O5S
[MDL Number]

MFCD00866494
[MOL File]

60084-10-8.mol
[Molecular Weight]

260.27
Chemical PropertiesBack Directory
[Melting point ]

145-146°
[alpha ]

D25 -9° (c = 0.5 in ethanol)
[density ]

1.4797 (rough estimate)
[refractive index ]

1.6800 (estimate)
[storage temp. ]

Keep in dark place,Inert atmosphere,2-8°C
[solubility ]

DMSO (Slightly), Methanol (Slightly, Heated), Water (Slightly)
[form ]

Solid
[color ]

White to Pale Beige
[Stability:]

Very Very Hygroscopic
Hazard InformationBack Directory
[Chemical Properties]

White Solid
[Uses]

Tiazofurin has antitumor activity and is a potential therapeutic agent in the treatment of cancer. Tiazofurin acts as an inhibitor of Inosine-5'-monophosphate (IMP) dehydrogenase.
[Definition]

ChEBI: A C-glycosyl compound that is 1,3-thiazole-4-carboxamide in which the hydrogen at position 2 has been replaced by a beta-D-ribofuranosyl group. It is metabolised to thiazole-4-carboxamide adenine dinucle tide (TAD), a selective inhibitor of inosine monophosphate dehydrogenase (IMP dehydrogenase).
[Brand name]

Tiazofurine is INN.
[storage]

Store at -20°C
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