| Identification | Back Directory | [Name]
Sancycline hydrochloride | [CAS]
6625-20-3 | [Synonyms]
Fda 0129
sancycline HCL
Bonomycin hydrochloride
Minocycline EP IMpurity B
6-DeMethyl-6-deoxytetracycline Hydrochloride
Minocycline Impurity 2(Minocycline EP Impurity B)
6-DeMethyl-6-deoxytetracycline hydrochloride, NSC 51812
2-Naphthacenecarboxamide, 4-dimethylamino-1,4,4A,5,5A,6,11,12A-octahydro-3,10,12,12A-tetrahydroxy-1,11-dioxo-, hydrochloride
4-(dimethylamino)-3,10,12,12a-tetrahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide hydrochloride (1:1)
(4S,4aS,5aR,12aS)-4-(Dimethylamino)-3,10,12,12a-tetrahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide HCl
(4S,4aS,5aR,12aS)-4-(DiMethylaMino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1-11-dioxo-2-naphthacenecarboxaMide Hydrochloride
2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4A,5,5A,6,11,12A-octahydro-3,10,12,12A-tetrahydroxy-1,11-dioxo-, monohydrochloride, [4S-(4.alpha.,4A.alpha.,5A.alpha.,12A.alpha.)]- | [Molecular Formula]
C21H23ClN2O7 | [MDL Number]
MFCD09842560 | [MOL File]
6625-20-3.mol | [Molecular Weight]
450.87 |
| Chemical Properties | Back Directory | [Melting point ]
224-2280C (dec.) | [storage temp. ]
-20°C Freezer | [solubility ]
DMF: 20mg/mL; DMSO: 20mg/mL; DMSO:PBS (pH 7.2) (1:5): 0.15 mg/mL; Ethanol: 5mg/mL | [form ]
A crystalline solid |
| Hazard Information | Back Directory | [Chemical Properties]
Yellow Solid | [Uses]
A semi-synthetic antibiotic related to Tetracycline. | [Uses]
Sancycline hydrochloride is the hydrochloride salt of a rare semi-synthetic tetracycline prepared by hydrogenolysis of the chloro and benzylic hydroxy moieties of declomycin, first reported in 1962. As the simplest of the early tetracyclines, sancycline was the first to be totally synthesised by Conover and co-workers. Like other tetracyclines, sancycline acts by reversibly binding to the 30S ribosomal subunit and inhibiting protein translation by blocking entry of aminoacyl-tRNA into the ribosome A site. |
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