ChemicalBook--->CAS DataBase List--->68124-04-9

68124-04-9

68124-04-9 Structure

68124-04-9 Structure
IdentificationBack Directory
[Name]

Chonglou Saponin VII
[CAS]

68124-04-9
[Synonyms]

Paris VII
Dioscinin
Chonglouoside Ⅶ
Paris saponin VII
Chonglou saponin Ⅶ
Chonglou Saponin VII
β-D-Glucopyranoside, (3β,25R)-17-hydroxyspirost-5-en-3-yl O-6-deoxy-α-L-mannopyranosyl-(1→2)-O-[O-6-deoxy-α-L-mannopyranosyl-(1→4)-6-deoxy-α-L-mannopyranosyl-(1→4)]-
[Molecular Formula]

C51H82O21
[MDL Number]

MFCD20260362
[MOL File]

68124-04-9.mol
[Molecular Weight]

1031.2
Chemical PropertiesBack Directory
[Melting point ]

243-245 °C (decomp)
[density ]

1.45±0.1 g/cm3(Predicted)
[storage temp. ]

-20°C, protect from light
[solubility ]

Soluble in methanol;
[form ]

powder
[pka]

12?+-.0.70(Predicted)
[color ]

White
[Water Solubility ]

sparingly soluble in water
Safety DataBack Directory
[HS Code ]

29329990
Hazard InformationBack Directory
[Chemical Properties]

White crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents.
[Uses]

Used for content determination/identification/pharmacological experiments, etc.
[Biological Activity]

Paris saponin VII (Chonglou Saponin VII) is a steroidal saponin isolated from the roots and rhizomes of Trillium tschonoskii Maxim. Paris saponin VII-induced apoptosis in K562/ADR cells is associated with inhibition of Akt/p38 MAPK and P-gp. It attenuates mitochondrial membrane potential, increases the expression of apoptosis-related proteins (Bax and cytochrome c), and reduces the protein expression levels of Bcl-2, caspase-9, caspase-3, PARP-1 and p-Akt. Paris saponin VII induces strong autophagy in K562/ADR cells, which can be used for leukemia research.
[Pharmacology]

Chonglou saponin VII has the functions of anti-inflammatory, anti-tumor, anti-viral, lowering cholesterol, lowering blood pressure and so on.
[in vitro]

Paris saponin VII (Chonglou Saponin VII) inhibits the growth of adriamycin-resistant human leukemia cells (K562/ADR) in a dose-dependent manner. It significantly suppresses cell proliferation by cell cycle arrest in the G0 /G1 phase.

[in vivo]

Paris saponin VII (Chonglou Saponin VII) (intravenous administration) significantly enhances anticancer efficacy of adriamycin to MCF-7/ADR xenograft model in nude mice.

[target]

Akt

p38

Bcl-2

Caspase-9

Caspase-3

PARP-1

Spectrum DetailBack Directory
[Spectrum Detail]

Chonglou Saponin VII(68124-04-9)1HNMR
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