| Identification | Back Directory | [Name]
streptazolin | [CAS]
80152-07-4 | [Synonyms]
streptazolin
Streptazoline
(+)-Streptazoline
(2aS,4Z)-3β-Hydroxy-4-ethylidene-2aβ,3,4,6,7,7bβ-hexahydro-2-oxa-7a-aza-1H-cyclopenta[cd]indene-1-one
1H-2-Oxa-7a-azacyclopent[cd]inden-1-one, 4-ethylidene-2a,3,4,6,7,7b-hexahydro-3-hydroxy-, (2aS,3S,4Z,7bS)- | [Molecular Formula]
C11H13NO3 | [MOL File]
80152-07-4.mol | [Molecular Weight]
207.23 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
Dichloromethane: soluble; DMSO: soluble; Ethanol: soluble; Methanol: soluble | [form ]
A solid |
| Hazard Information | Back Directory | [Description]
Streptazolin is a fungal metabolite originally isolated from S. viridochromogenes.1 It increases NF-κB activity when used at concentrations ranging from 60 to 130 μg/ml, at least in part, via PI3K signaling.2 Streptazolin enhances TNF-α secretion induced by LPS and enhances IL-8 secretion when used alone or in combination with LPS in THP-1 Blue cells. | [References]
1. Drautz, H., Zaehner, H., Kupfer, E., et al. Metabolic products of microorganisms. 205. Isolation and structure of streptazolin Helv. Chim. Acta. 64(6),1752-1765(1981).
2. Perry, J.A., Koteva, K., Verschoor, C.P., et al. A macrophage-stimulating compound from a screen of microbial natural products J. Antibiot. (Tokyo) 68(1),40-46(2015). |
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