| Identification | Back Directory | [Name]
(8S,15S)-DIHETE | [CAS]
80234-65-7 | [Synonyms]
(8S,15S)-DIHETE
8(S),15(S)-DiHETE (Z, E, Z, E)
8(S),15(S)DiHETE,8(S),15(S) DiHETE
(8S,15S)-dihydroxy-(5Z,9E,11Z,13E)-*eicosatetraen
(8S,15S)-DIHYDROXY-(5Z,9E,11Z,13E)-EICOS ATETRAENOI
(8S,15S)-DIHYDROXY-(5Z,9E,11Z,13E)-EICOSATETRAENOIC ACID
8(S),15(S)-DIHYDROXYEICOSA-5Z,9E,11Z,13E-TETRAENOIC ACID
5,9,11,13-Eicosatetraenoic acid, 8,15-dihydroxy-, (5Z,8S,9E,11Z,13E,15S)- | [Molecular Formula]
C20H32O4 | [MDL Number]
MFCD00063587 | [MOL File]
80234-65-7.mol | [Molecular Weight]
336.47 |
| Hazard Information | Back Directory | [Description]
8(S),15(S)-DiHETE is formed when 15(S)-HETE is subjected to further oxidation by 15-LO. It causes eosinophil chemotaxis with an ED50 value of 1.5 μM but is not chemotactic for neutrophils. 8(S),15(S)-DiHETE antagonizes the hyperalgesic activity of 8(R),15(S)-DiHETE and LTB4 in the rat hind paw pain model. | [Uses]
8(S),15(S)-DiHETE (Z, E, Z, E) is a novel dioxygenation product of arachidonic acid. | [Definition]
ChEBI: 8(S),15(S)-DiHETE is ab 8,15-DiHETE that is derived from (5Z,9E,11Z,13E)-icosatetraenoic acid and has (8S,15S)-stereochemistry. It has a role as a human xenobiotic metabolite and a mouse metabolite. It is functionally related to an arachidonic acid. It is a conjugate acid of an 8(S),15(S)-DiHETE(1-). |
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