| Identification | Back Directory | [Name]
d-Epigalbacin | [CAS]
84709-25-1 | [Synonyms]
epigalbacin
(-)-Zuonin A
d-Epigalbacin
1,3-Benzodioxole, 5,5'-[(2S,3R,4S,5S)-tetrahydro-3,4-dimethyl-2,5-furandiyl]bis- | [Molecular Formula]
C20H20O5 | [MOL File]
84709-25-1.mol | [Molecular Weight]
340.37 |
| Hazard Information | Back Directory | [Biological Activity]
(-)-Zuonin A (D-Epigalbacin), a natural lignin, is a potent and selective inhibitor of JNKs with IC50 values of 1.7 μM, 2.9 μM and 1.74 μM for JNK1, JNK2 and JNK3, respectively. | [in vitro]
(?)-zuonin A binds the D-recruitment site (DRS) of JNK, a recruitment site utilized by substrates and other substrates to dock onto and recognize MAPKs.
(?)-zuonin A
| [target]
| JNK1 1.7 μM (IC 50 ) | JNK2 2.9 μM (IC 50 ) | JNK3 1.74 μM (IC 50 ) | |
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cjbscvictory
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http://www.weikeqi-biotech.com/ |
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