| Identification | Back Directory | [Name]
SB 203580 (hydrochloride) | [CAS]
869185-85-3 | [Synonyms]
RWJ 64809 hydrochloride
SB 203580, Hydrochloride - CAS 869185-85-3 - Calbiochem
RWJ 64809 HYDROCHLORIDE;SB203580 HYDROCHLORIDE;SB-203580 HYDROCHLORIDE | [Molecular Formula]
C21H17ClFN3OS | [MDL Number]
MFCD01862622 | [MOL File]
869185-85-3.mol | [Molecular Weight]
413.896 |
| Chemical Properties | Back Directory | [storage temp. ]
-20C | [solubility ]
insoluble in EtOH; insoluble in H2O; ≥20.7 mg/mL in DMSO | [form ]
Bright yellow solid | [Water Solubility ]
Soluble to 25 mM in water | [Stability:]
Hygroscopic |
| Hazard Information | Back Directory | [Uses]
SB 203580 Hydrochloride is a protein kinase inhibitor. | [General Description]
A water-soluble form of the potent MAP kinase inhibitor SB 203580 (Cat. No. 559389). | [Biological Activity]
sb203580 hcl is a specific inhibitor of p38-mapks with ic50 value of 0.6 μm [1].sb203580 is an inhibitor of p38-mapkα and p38-mapkβ. in neonatal myocytes, sb203580 prevented p38-mapk from activating mapkapk2 with ic50 value of 70 nm. it also significantly suppressed mapkapk2 activation in by il-1, osmotic stress or arsenite in kb cells. in neonatal rat ventricular myocytes, sb203580 inhibited jnk activity of activating c-jun with ic50 value of 3-10 μm. besides that, sb203580 affected the phosphorylation of small heat shock proteins caused by mapkapk2. it inhibited the il-1-, chemical- or osmotic stress-stimulated hsp27 phosphorylation with ic50 value of < 1μm in kb cells [1, 2]. | [Biochem/physiol Actions]
Cell permeable: yes | [storage]
Store at -20°C | [References]
[1] cuenda a, rouse j, doza y n, et al. sb 203580 is a specific inhibitor of a map kinase homologue which is stimulated by cellular stresses and interleukin-1. febs letters, 1995, 364(2): 229-233.
[2] clerk a, sugden p h. the p38-mapk inhibitor, sb203580, inhibits cardiac stress-activated protein kinases/c-jun n-terminal kinases (sapks/jnks). febs letters, 1998, 426(1): 93-96. |
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