ChemicalBook--->CAS DataBase List--->882257-11-6

882257-11-6

882257-11-6 Structure

882257-11-6 Structure
IdentificationBack Directory
[Name]

P-5091
[CAS]

882257-11-6
[Synonyms]

P5091
P-5091
P 5091
CS-726
P005091
P-005091
P 005091
P5091, >=98%
P005091(P5091)
P5091 (P005091)
P-5091 USP/EP/BP
P5091; P-005091; P 005091; P 5091; P-5091
1-[5-[(2,3-Dichlorophenyl)thio]-4-n-itro-2-thienyl]ethanone
1-(5-(2,3-dichlorophenylthio)-4-nitrothiophen-2-yl)ethanone
1-[5-(2,3-dichlorophenyl)sulfanyl-4-nitro-2-thienyl]ethanone
Ethanone, 1-[5-[(2,3-dichlorophenyl)thio]-4-nitro-2-thienyl]-
1-[5-(2,3-Dichloro-phenylsulfanyl)-4-nitro-thiophen-2-yl]-ethanone
1-[5-[(2,3-Dichlorophenyl)thio]-4-nitro-2-thienyl]-ethanone P005091
[Molecular Formula]

C12H7Cl2NO3S2
[MDL Number]

MFCD00123202
[MOL File]

882257-11-6.mol
[Molecular Weight]

348.22
Chemical PropertiesBack Directory
[Boiling point ]

452.4±45.0 °C(Predicted)
[density ]

1.60±0.1 g/cm3(Predicted)
[storage temp. ]

2-8°C
[solubility ]

DMSO: soluble10mg/mL, clear
[form ]

powder
[color ]

light yellow to dark yellow
[Stability:]

Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Safety DataBack Directory
[Hazard Codes ]

T
[Risk Statements ]

25
[Safety Statements ]

45
[RIDADR ]

UN 2811 6.1 / PGIII
[WGK Germany ]

3
Hazard InformationBack Directory
[Description]

P5091 (882257-11-6) is a selective inhibitor of the ubiquitin-specific protease USP7 ( IC50=4.2 μM).1,2 Induces apoptosis in multiple myeloma cells and overcomes bortezomib resistance.1?P5091 displays antiangiogenic activity in vivo.2?Cell permeable
[Uses]

P005091 is a selective dual inhibitor of the cancer-related deubiquitylating proteases USP7 and USP47.
[Biochem/physiol Actions]

P5091 plays an important role in ovarian cancer, as it can prevent the growth of cells and can promote necrosis and apoptosis.
[storage]

Store at 4°C
[References]

1) Chauhan et al. (2012), A small molecule inhibitor of ubiquitin-specific protease-7 induces apoptosis in multiple myeloma cells and overcomes bortezomib resistance; Cancer Cell, 22 345 2) Weinstock et al. (2012), Selective dual inhibitors of the cancer-related deubiquitylating proteases USP7 and USP47; ACS Med. Chem. Lett., 3 789
Spectrum DetailBack Directory
[Spectrum Detail]

P-5091(882257-11-6)1HNMR
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