| Identification | Back Directory | [Name]
25-hydroxy Cholesterol-d6 | [CAS]
88247-69-2 | [Synonyms]
25-hydroxy Cholesterol-d6
cholest-5-ene-3,25-diol-d6
CHOLEST-5-ENE-3,25-DIOL-D6;25-HYDROXYCHOLESTEROL-D6
(3S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-[(2R)-7,7,7-trideuterio-6-hydroxy-6-(trideuteriomethyl)heptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol | [Molecular Formula]
C27H40D6O2 | [MOL File]
88247-69-2.mol | [Molecular Weight]
408.69 |
| Chemical Properties | Back Directory | [Melting point ]
>155°C (dec.) | [storage temp. ]
-20°C | [solubility ]
Chloroform (Slightly), DMSO (Slightly, Sonicated), Methanol (Slightly, Sonicated | [form ]
Solid | [color ]
White to Off-White |
| Hazard Information | Back Directory | [Uses]
25-Hydroxy Cholesterol-d6, is the labeled analogue of 25-Hydroxy Cholesterol (H918030), which is an oxygenated derivative of Cholesterol (C432501); an oxysterol. An inhibitor of human immunodeficiency virus replication in vitro. It also induces apoptosis in human monocytic cell lines as well as inducing apoptosis in CEM cells associated with negative regulation of c-Myc. | [General Description]
25-hydroxycholesterol (25HC) is synthesized from cholesterol in the presence of oxygen and enzyme cholesterol 25-hydroxylase and the conversion is dependent on nicotinamide adenine dinucleotide phosphate (NADPH) during toll-like receptor activation. 25HC is catabolized to 7α-hydroxylated sterol. 25-hydroxycholesterol-d6 is the deuterated form of 25-hydroxycholesterol. | [Biochem/physiol Actions]
25-hydroxycholesterol inhibits cholesterol biosynthesis by downregulating the function of 3-hydroxy-3-methylglutaryl-CoA reductase. It is found to be implicated in atherosclerosis. 25-hydroxycholesterol levels are known to be increased in hypercholesterolemic condition. |
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