| Identification | Back Directory | [Name]
LEVCROMAKALIM | [CAS]
94535-50-9 | [Synonyms]
brl38227
lemakalim
Brn 3622889
LevkroMakaliM
levcromakelim
LEVCROMAKALIM
(3s-trans)-yrrolidinyl)
Potassium Channel,KcsA,Inhibitor,inhibit,BRL38227,BRL-38227,Levcromakalim
(3β,4α)-3-Hydroxy-2,2-dimethyl-4-(2-oxopyrrolidin-1-yl)chroman-6-carbonitrile
(3S,4R)-3-hydroxy-2,2-dimethyl-4-(2-oxopyrrolidin-1-yl)chroman-6-carbonitrile
2h-1-benzopyran-6-carbonitrile,3,4-dihydro-3-hydroxy-2,2-dimethyl-4-(2-oxo-1-p
(3S,4R)-3β-Hydroxy-4-(2-oxopyrrolizino)-2,2-dimethyl-3,4-dihydro-6-cyano-2H-1-benzopyran
(3β,4α)-3,4-Dihydro-3-hydroxy-2,2-dimethyl-4-(2-oxopyrrolidin-1-yl)-2H-1-benzopyran-6-carbonitrile
(3S,4R)-3,4-DIHYDRO-3-HYDROXY-2,2-DIMETHYL-4-(2-OXO-1-PYRROLIDINYL)-2H-1-BENZOPYRAN-6-CARBONITRILE
2H-1-Benzopyran-6-carbonitrile, 3,4-dihydro-3-hydroxy-2,2-dimethyl-4-(2-oxo-1-pyrrolidinyl)-, (3S,4R)-
2H-1-Benzopyran-6-carbonitrile, 3,4-dihydro-3-hydroxy-2,2-dimethyl-4-(2-oxo-1-pyrrolidinyl)-, (3S,trans)- | [Molecular Formula]
C16H18N2O3 | [MDL Number]
MFCD00864806 | [MOL File]
94535-50-9.mol | [Molecular Weight]
286.33 |
| Chemical Properties | Back Directory | [Melting point ]
242-244° | [alpha ]
D26 -52.2° (c = 1 in chloroform) | [Boiling point ]
482.3±45.0 °C(Predicted) | [density ]
1.31±0.1 g/cm3(Predicted) | [storage temp. ]
Store at RT | [solubility ]
DMSO: ≤10 mM, soluble
| [form ]
solid
| [pka]
13.18±0.60(Predicted) |
| Hazard Information | Back Directory | [Uses]
Anti-asthmatic; antihypertensive. | [Definition]
ChEBI: Levcromakalim is a 1-benzopyran. | [Biological Activity]
Active enantiomer of the prototypical K ATP channel opener cromakalim (trans-3,4-dihydro-3-hydroxy-2,2-dimethyl-4-(2-oxo-1-pyrrolidinyl)-2H-1-benzopyran-6-carbonitrile ). Hypotensive and airways relaxant. IC 50 = 490 nM in guinea pig trachea. | [storage]
Store at RT |
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cjbscvictory
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13348960310 13348960310 |
| Website: |
http://www.weikeqi-biotech.com/ |
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