| Identification | Back Directory | [Name]
D-(-)-MANDELIC ACID BENZYL ESTER | [CAS]
97415-09-3 | [Synonyms]
DOMIT-002
(R)-BENZYL MANDELATE
BENZYL D-(-)-MANDELATE
BENZYL (R)-(-)-MANDELATE
BenzylD-(-)-Mandelate>
Benzyl (R)-(-)-mandelate 99%
D-(-)-MANDELIC ACID BENZYL ESTER
-Benzyl 2-hydroxy-2-phenylacetate
(R)-Benzyl 2-hydroxy-2-phenylacetate
benzyl (2R)-2-hydroxy-2-phenylacetate
Benzyl D-(-)-Mandelate
Benzyl-(R)-Mandelate / Benzyl-(D)-Mandelate
ALPHA-HYDROXY-BENZENEACETIC ACID, PHENYLMETHYL ESTER
D-(-)-MANDELIC ACID BENZYL ESTER ISO 9001：2015 REACH
Benzeneacetic acid, α-hydroxy-, phenylmethyl ester, (αR)- | [EINECS(EC#)]
1312995-182-4 | [Molecular Formula]
C15H14O3 | [MDL Number]
MFCD00674031 | [MOL File]
97415-09-3.mol | [Molecular Weight]
242.27 |
| Chemical Properties | Back Directory | [Melting point ]
104-107 °C(lit.)
| [Boiling point ]
387℃ | [density ]
1.204 | [refractive index ]
-34 ° (C=1, CH3CN) | [Fp ]
163℃ | [storage temp. ]
Sealed in dry,Room Temperature | [solubility ]
DMF: 30 mg/ml; DMF:PBS (pH 7.2) (1:2): 0.3 mg/ml; DMSO: 25 mg/ml; Ethanol: 20 mg/ml | [form ]
powder to crystal | [pka]
12.15±0.20(Predicted) | [color ]
White to Almost white | [optical activity]
[α]25/D 55°, c = 1 in chloroform | [CAS DataBase Reference]
97415-09-3 |
| Hazard Information | Back Directory | [Description]
(R)-benzyl Mandelate is a synthetic intermediate useful for pharmaceutical synthesis. | [Uses]
Benzyl (R)-(-)-mandelate can be employed as reactant to synthesize:
- (S)-α-Hydroxy-N-(2-phenylethyl)benzenepropanamide (α-hydroxyamides) by enzyme catalyzed amidation reaction.
- Optically pure (R)- monomethyl esters of 3-[(tert-butyldimethylsilyl)oxy]pentanedioic acid, which is employed in the preparation of HMG-CoA reductase inhibitors.
- O-Ibuprofenylmandelic acid via acylation reaction with optically active ibuprofen and subsequent hydrogenation.
- Benzyl (R)-2-fluoro-2-phenylacetate via deoxyfluorination of alcohols using AlkylFluor.
It can also be used to prepare HMG-CoA reductase inhibitors. | [Uses]
D-(-)-Mandelic Acid Benzyl Ester is a useful reagent for the preparation of a pharmaceutical composition for treating atopic dermatitis. |
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