101236-49-1
101236-49-1 结构式
基本信息
中文别名
苦参醇K苦参醇K对照品
苦参醇K标准品
英文别名
Kushenol Kproduct/154906
(2R,3S)-2-(2,4-Dihydroxyphenyl)-2,3-dihydro-3,7-dihydroxy-8-[(2R)-5-hydroxy-5-methyl-2-(1-methylethenyl)hexyl]-5-methoxy-4H-1-benzopyran-4-one
4H-1-Benzopyran-4-one, 2-(2,4-dihydroxyphenyl)-2,3-dihydro-3,7-dihydroxy-8-[(2R)-5-hydroxy-5-methyl-2-(1-methylethenyl)hexyl]-5-methoxy-, (2R,3S)-
常见问题列表
生物活性
Kushenol K,一种从 Sophora flavescens 中提取的黄酮类抗氧化剂。Kushenol K 是 CYP3A4 的抑制剂,Ki 值为 1.35 μM。Kushenol K 对 HSV-2 具有较弱的抗病毒活性 (EC50 为 147 μM)。Kushenol K 还抑制 SGLT1 和 SGLT2 的活性。靶点
HSV-2 147 μM (EC 50 ) |
CYP3A4 1.35 μM (Ki) |
SGLT
|
体外研究
When Midazolam is used as the substrate of CYP3A4, Kushenol K exhibits the strong inhibition with an IC
50
values of 1.62 µM.
At a concentration of 50 μM, the inhibition rate of Kushenol K on SGLT1 is 29.7%, and the inhibition rate on SGLT2 is 43.7%.