101246-66-6
中文名称
苯丝氨酸
英文名称
PHENSERINE
CAS
101246-66-6
分子式
C20H23N3O2
分子量
337.42
MOL 文件
101246-66-6.mol
更新日期
2024/02/18 15:45:21
101246-66-6 结构式
基本信息
中文别名
苯丝氨酸 英文别名
PHENSERINE(3as-cis)-amate(ester
(-)-Eseroline phenylcarbamate
(-)-N-PHENYLCARBAMOYLESEROLINE
3-b)indol-5-ol,1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethyl-pyrrolo(phenylcarb
1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethyl-pyrrolo[2,3-b]indol-5-ol phenylcarbamate (ester)
(3aS,8aR)-1,2,3,3a,8,8a-Hexahydro-1,3a,8-trimethylpyrrolo[2,3-b]indol-5-ol5-(N-phenylcarbamate)
Pyrrolo[2,3-b]indol-5-ol, 1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethyl-, 5-(N-phenylcarbamate), (3aS,8aR)-
物理化学性质
熔点151-152 °C
沸点468.7±45.0 °C(Predicted)
密度1.228±0.06 g/cm3(Predicted)
储存条件2-8°C
溶解度H2O:<2毫克/毫升
酸度系数(pKa)13.05±0.70(Predicted)
形态固体
颜色米白色
苯丝氨酸价格(试剂级)
报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
2024/04/30 | HY-103374 | 苯丝氨酸 Phenserine | 101246-66-6 | 10mM * 1mLin DMSO | 1559元 |
2024/04/30 | HY-103374 | 苯丝氨酸 Phenserine | 101246-66-6 | 5mg | 2100元 |
2024/04/30 | HY-103374 | 苯丝氨酸 Phenserine | 101246-66-6 | 10mg | 3500元 |
常见问题列表
生物活性
Phenserine ((-)-Eseroline phenylcarbamate) 是 Physostigmine 的衍生物,是一种有效的,非竞争性,长效和选择性的 AChE 抑制剂。Phenserine 可减少 β-淀粉样蛋白前体蛋白 (APP) 和 β-淀粉样肽 (Aβ) 的形成。Phenserine 可改善认知能力并减轻阿尔茨海默氏病的进展。靶点
AChE; β-amyloid precursor protein; β-amyloid peptide
体外研究
Phenserine (1-25 μM; 48 hours; CHO APP 751SW cells) treatment CHO APP 751SW cell shows 18.6% reduction in cells treated with 10 μM of Phenserine, while 25 μM concentration of Phenserine reduces APP level by 51.4%.
Western Blot Analysis
Cell Line: | CHO APP 751SW cells |
Concentration: | 1 μM, 2.5 μM, 5 μM, 10 μM, 25 μM |
Incubation Time: | 48 hours |
Result: | 8.6% reduction in cells treated with 10 μM, while 25 μM concentration reduces APP level by 51.4%. |
体内研究
Phenserine (1-4 mg/kg; intraperitoneal injection; for 4 days; male Fischer-344 rats) treatment improves learning when cholinergic function has been impaired in a spatial memory task.
Animal Model: | Male Fischer-344 rats (5 months old) induced by scopolamine |
Dosage: | 1 mg/kg, 2 mg/kg, 4 mg/kg |
Administration: | Intraperitoneal injection; for 4 days |
Result: | Improved morris water maze performance of scopolamine-treated rats.. |