102841-42-9
中文名称
桑皮苷A
英文名称
mulberroside A
CAS
102841-42-9
分子式
C26H32O14
分子量
568.52
MOL 文件
102841-42-9.mol
更新日期
2024/05/27 15:49:30
102841-42-9 结构式
基本信息
中文别名
桑皮苷A桑皮苷A对照品,
桑皮苷A(标准品)
桑皮苷A, 来源于桑树
桑皮苷A(分析标准品)
MULBERROSIDE A 桑皮苷A
英文别名
mulberroside AMulberroside A, 98%, from Morus alba L.
2,5'-Dihydroxy-4,3'-bis(β-D-glucopyranosyloxy)-trans-stilbene
2,5'-Dihydroxy-4,3'-bis(beta-D-glucopyranosyloxy)-trans-stilbene
b-D-Glucopyranoside,3-[(1E)-2-[4-(b-D-glucopyranosyloxy)-2-hydroxyphenyl]ethenyl]-5-hydroxyphenyl
β-D-Glucopyranoside, 3-[(1E)-2-[4-(β-D-glucopyranosyloxy)-2-hydroxyphenyl]ethenyl]-5-hydroxyphenyl
2-(4-hydroxy-1,3-thiazol-3-ium-3-yl)ethyl [2-(octadecylcarbamoyloxymethyl)oxolan-2-yl]methyl phosphate
beta-D-Glucopyranoside 3-[(1E)-2-[4-(beta-D-glucopyranosyloxy)-2-hydroxyphenyl]ethenyl]-5-hydroxyphenyl
所属类别
生物化工：提取物物理化学性质
外观性状白色结晶粉末，可溶于甲醇、乙醇、DMSO等有机溶剂，来源于桑白皮。
熔点235-236o C
沸点954.7±65.0 °C(Predicted)
密度1.654
闪点531℃
储存条件Hygroscopic, -20°C Freezer, Under inert atmosphere
溶解度DMSO（轻微，超声处理），甲醇（轻微）
酸度系数(pKa)9.03±0.40(Predicted)
形态固体
颜色白色至灰白色
常见问题列表
生物活性
Mulberroside A 是从 Morus alba 根的乙醇提取物中分离出的，具有抗酪氨酸酶和抗氧化活性，并被广泛用作化妆品中的活性成分。Mulberroside A 降低 TNF-α、IL-1β 和 IL-6 的表达并抑制 NALP3、caspase-1 和 NF-κB 的激活以及 ERK、JNK 和 p38 的磷酸化。体内研究
Mulberroside A (10, 20, and 40 mg/kg) decreases serum uric acid levels and increases urinary urate excretion and fractional excretion of uric acid in hyperuricemic micem.
| Animal Model: | Male Kun-Ming mice (20±2 g) |
| Dosage: | 5, 10, 20, and 40 mg/kg; the dose volume 10 mL/kg body weight |
| Administration: | Orally initiated at 9:00 a.m. |
| Result: | 10, 20, and 40 mg/kg significantly increased urinary urate excretion in 24 h, resulting in a remarkable elevation of fractional excretion of uric acid (FEUA), and the highest dose completely reversed FEUA alteration of hyperuricemic mice to normal. |