107220-29-1

中文名称反式西维美林盐酸盐

英文名称 trans-Cevimeline Hydrochloride

CAS 107220-29-1

分子式 C10H18ClNOS

分子量 235.774

MOL 文件 107220-29-1.mol

107220-29-1 结构式

基本信息物理化学性质安全数据应用领域

基本信息

中文别名

化合物 T29681
TRANS-CEVIMELINE HCL

英文别名

AF 102A HCl
trans-Cevimeline HCl
rac,trans-Cevimeline Hydrochloride
Cevimeline Impurity 7(trans-Cevimeline HCl)
(2S)-2-methylspiro[1,3-oxathiolane-5,3'-1-azabicyclo[2.2.2]octane]:hydrochloride

物理化学性质

溶解度可溶于氯仿（少许）、甲醇（少许）

形态固体

颜色白色至灰白色

稳定性吸湿性

安全数据

危险性符号(GHS)

GHS08,GHS06

警示词危险

危险性描述H361-H301-H351-H332

防范说明P201-P202-P281-P308+P313-P405-P501-P201-P202-P281-P308+P313-P405-P501-P264-P270-P301+P310-P321-P330-P405-P501-P261-P271-P304+P340-P312

应用领域

用途一

trans-Cevimeline HCl, also known as AF 102A, is the trans-isomer of AF102B (Cevimeline). Cevimeline is a cholinergic analogue with glandular secretion stimulatory activity. Cevimeline binds to and activates muscarinic receptors, thereby increasing the secretions in exocrine salivary and sweat glands. This cholinergic agonist also increases the tone of smooth muscle in the gastrointestinal and urinary tracts. Cevimeline is being studied as a treatment for dry mouth caused by radiation therapy to the head and neck.