1073612-91-5

中文名称 4-[[2-硫代-3-(3-三氟甲基苄基)-4-氧代噻唑烷-5-亚基]甲基]苯甲酸

英文名称 CY-09

CAS 1073612-91-5

分子式 C19H12F3NO3S2

分子量 423.43

MOL 文件 1073612-91-5.mol

更新日期 2024/06/07 17:54:50

1073612-91-5 结构式

基本信息物理化学性质 4-[[2-硫代-3-(3-三氟甲基苄基)-4-氧代噻唑烷-5-亚基]甲基]苯甲酸价格(试剂级) 常见问题列表

基本信息

中文别名

化合物CY09
4-[[2-硫代-3-(3-三氟甲基苄基)-4-氧代噻唑烷-5-亚基]甲基]苯甲酸
4-((4-氧代-2-硫代-3-(3-(三氟甲基)苄基)噻唑烷-5-亚基)甲基)苯甲酸

英文别名

CY-09
CS-2756
CY 09
CY09
CY09
CY 09
CY-09
4-[[4-Oxo-2-thioxo-3-[3-(trifluoromethyl)benzyl]thiazolidin-5-ylidene]methyl]benzoic Acid
(E)-4-((4-oxo-2-thioxo-3-(3-(trifluoromethyl)benzyl)thiazolidin-5-ylidene)methyl)benzoic acid
4-[[4-Oxo-2-thioxo-3-[[3-(trifluoromethyl)phenyl]methyl]-5-thiazolidinylidene]methyl]benzoic acid
Benzoic acid, 4-[[4-oxo-2-thioxo-3-[[3-(trifluoromethyl)phenyl]methyl]-5-thiazolidinylidene]methyl]-

物理化学性质

储存条件-20°C储存

溶解度DMSO:65.0(Max Conc. mg/mL);152.61(Max Conc. mM)

形态结晶固体

4-[[2-硫代-3-(3-三氟甲基苄基)-4-氧代噻唑烷-5-亚基]甲基]苯甲酸价格(试剂级)

报价日期	产品编号	产品名称	CAS号	包装	价格
2024/04/30	HY-103666	4-[[2-硫代-3-(3-三氟甲基苄基)-4-氧代噻唑烷-5-亚基]甲基]苯甲酸 CY-09	1073612-91-5	5mg	900元
2024/04/30	HY-103666	4-[[2-硫代-3-(3-三氟甲基苄基)-4-氧代噻唑烷-5-亚基]甲基]苯甲酸 CY-09	1073612-91-5	10mM * 1mLin DMSO	990元
2024/04/30	S5774	4-[[2-硫代-3-(3-三氟甲基苄基)-4-氧代噻唑烷-5-亚基]甲基]苯甲酸 CY-09	1073612-91-5	5mg	1204.51元

常见问题列表

生物活性

CY-09是一种特异的NLRP3 inflammasome的抑制剂，直接靶向NLRP3。它对5种主要的cytochrome P450酶的IC50值分别为18.9, 8.18, >50, >50 和 26.0 µM。

靶点

Target	Value
NLRP3 inflammasome ()

体外研究

CY-09 exhibits a dose-dependent inhibitory effect on monosodium urate (MSU), nigericin, ATP-induced caspase-1 activation and IL-1β secretion at the doses of 1 to10 µM in LPS-primed bone marrow-derived macrophages (BMDMs). Cytosolic LPS-induced noncanonical NLRP3 activation in BMDMs can also be blocked by CY-09 treatment. CY-09 specifically inhibits NLRP3 inflammasome activation and has no effect on LPS-induced priming effects. CY-09 treatment remarkably suppresses nigericin-induced ASC oligomerization. It is found that CY-09 treatment inhibits the interaction of Flag-NLRP3 and mCherry-NLRP3 in HEK-293T cells, suggesting that CY-09 blocks NLRP3 oligomerization.

体内研究

CY-09 treatment in vivo efficiently suppresses monosodium urate (MSU) injection-induced IL-1β production and neutrophil influx, suggesting that CY-09 can block MSU-induced NLRP3 inflammasome activation in vivo . CY-09 treatment also increases the survival of NLRP3 mutant mice up to days 30 to 48 even after treatment is stopped at day 25. The caspase-1 cleavage observed in adipose tissue of high-fat diet (HFD)-treated mice is also suppressed by CY-09.