107910-75-8
107910-75-8 结构式
基本信息
注射更昔洛韦
更昔洛韦杂质7
更昔洛韦钠原料药
更昔洛韦钠(二水)
更昔洛韦钠[干冰运输,需加收额外费用]
9-(1,3-二羟基-2-丙氧甲基)-鸟嘌呤钠
Rs 21592 sodium
GANCICLOVIR SODIUM
Sodium Ganciclovir
Cytovene IV sodium
Gancyclovir sodium
Ganciclovir Impurity 7
Ganciclovir Sodium Salt
Ganciclovir sodium, >=98%
Ganciclovir monosodium salt
物理化学性质
常见问题列表
2．预防可能发生于接受器官移植者的巨细胞病毒感染。
2. 预防可能发生于接受器官移植者的巨细胞病毒感染：肾功能正常者：静脉滴注，一次5mg/kg，每12小时一次，连用7天～14天后，改为一次5mg/kg，一日1次，一周用7天，或一次6 mg/kg，一日1次，每周用5天，或遵医嘱。每次静脉滴注时间不少于1小时。
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CMV
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HSV-1
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HSV-2
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FHV-1 5.2 μM (IC 50 ) |
Ganciclovir sodium is an acyclic deoxyguanosine analog structurally similar to acyclovir but with superior activity against CMV. The median ganciclovir concentration required to inhibit viral replication by 50 percent is 2.15 mumol versus 72 mumol for acyclovir.The primary mechanism of ganciclovir action against CMV is inhibition of the replication of viral DNA by ganciclovir-5'-triphosphate (ganciclovir-TP). This inhibition includes a selective and potent inhibition of the viral DNA polymerase. Ganciclovir sodium is metabolized to the triphosphate form by primarily three cellular enzymes: a deoxyguanosine kinase induced by CMV-infected cells; guanylate kinase; and phosphoglycerate kinase.
Ganciclovir sodium (1-80 mg/kg; i.h.; daily for 5 days) delays MCMV-induced wasting syndrome and mortality.
| Animal Model: | Severe combined immunodeficiency (SCID) mice (MCMV infection) |
| Dosage: | 1-80 mg/kg |
| Administration: | I.h.; daily for 5 days |
| Result: | Dose dependently delayed MCMV-induced wasting syndrome and mortality. |